Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Department of Pathology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Sci Rep. 2018 Jul 3;8(1):10018. doi: 10.1038/s41598-018-28397-8.
The roles of B and plasma cells in the pathogenesis of inflammatory bowel disease (IBD) are largely unrevealed. Data on the characteristics of IgG4 in patients with IBD are scarce. In this case-control study, serum IgG4 levels were comparable between patients with IBD and healthy individuals, whereas patients with IBD had dramatically higher mucosal IgG4 counts than healthy individuals. In patients with UC, mucosal IgG4 counts were positively correlated with serum IgG4 levels, serum IgG4/IgG ratios, and the Mayo Index; serum IgG4 levels and IgG4/IgG ratios were associated with a history of intestinal surgery and medications. A significant mucosal IgG4 count was found in 33.3% of patients with IBD, whereas, elevated serum IgG4 levels were found in only 9.9% of patients with IBD. Lesions were more severe and extensive in IBD patients with high levels of serum and mucosal IgG4. High levels of serum and mucosal IgG4 decreased after treatment with glucocorticoids or other immunosuppressants. High IgG4 level may be a biomarker for a new subset of IBD. More studies are warranted to explore this new subset of IBD for personalized therapy in the future.
B 细胞和浆细胞在炎症性肠病（IBD）发病机制中的作用在很大程度上尚未阐明。关于 IBD 患者 IgG4 的特征的数据很少。在这项病例对照研究中，IBD 患者的血清 IgG4 水平与健康个体相当，而 IBD 患者的黏膜 IgG4 计数明显高于健康个体。在 UC 患者中，黏膜 IgG4 计数与血清 IgG4 水平、血清 IgG4/IgG 比值和 Mayo 指数呈正相关；血清 IgG4 水平和 IgG4/IgG 比值与肠道手术和药物治疗史有关。在 33.3%的 IBD 患者中发现了明显的黏膜 IgG4 计数，而在 9.9%的 IBD 患者中仅发现了升高的血清 IgG4 水平。血清和黏膜 IgG4 水平高的 IBD 患者的病变更严重、更广泛。使用糖皮质激素或其他免疫抑制剂治疗后，血清和黏膜 IgG4 水平降低。高 IgG4 水平可能是 IBD 的一个新亚群的生物标志物。未来需要更多的研究来探索这种新的 IBD 亚群，以便为个体化治疗提供依据。
