正电子发射断层扫描-磁共振成像在肌肉骨骼疾病中的应用。
Applications of PET-MRI in musculoskeletal disease.
机构信息
Department of Radiology, Stanford University, Stanford, California, USA.
Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
出版信息
J Magn Reson Imaging. 2018 Jul;48(1):27-47. doi: 10.1002/jmri.26183.
UNLABELLED
New integrated PET-MRI systems potentially provide a complete imaging modality for diagnosis and evaluation of musculoskeletal disease. MRI is able to provide excellent high-resolution morphologic information with multiple contrast mechanisms that has made it the imaging modality of choice in evaluation of many musculoskeletal disorders. PET offers incomparable abilities to provide quantitative information about molecular and physiologic changes that often precede structural and biochemical changes. In combination, hybrid PET-MRI can enhance imaging of musculoskeletal disorders through early detection of disease as well as improved diagnostic sensitivity and specificity. The purpose of this article is to review emerging applications of PET-MRI in musculoskeletal disease. Both clinical applications of malignant musculoskeletal disease as well as new opportunities to incorporate the molecular capabilities of nuclear imaging into studies of nononcologic musculoskeletal disease are discussed. Lastly, we discuss some of the technical considerations and challenges of PET-MRI as they specifically relate to musculoskeletal disease.
LEVEL OF EVIDENCE
5 TECHNICAL EFFICACY: Stage 3 J. Magn. Reson. Imaging 2018;48:27-47.
未加标签
新的集成 PET-MRI 系统有可能为肌肉骨骼疾病的诊断和评估提供一种完整的成像方式。MRI 能够提供具有多种对比机制的出色高分辨率形态信息，使其成为评估许多肌肉骨骼疾病的首选成像方式。PET 提供了无与伦比的能力，可以提供有关分子和生理变化的定量信息，这些变化通常先于结构和生化变化。结合使用，混合 PET-MRI 可以通过早期发现疾病以及提高诊断的敏感性和特异性来增强肌肉骨骼疾病的成像。本文的目的是综述 PET-MRI 在肌肉骨骼疾病中的新兴应用。讨论了恶性肌肉骨骼疾病的临床应用以及将核成像的分子功能纳入非肿瘤性肌肉骨骼疾病研究的新机会。最后，我们讨论了 PET-MRI 与肌肉骨骼疾病具体相关的一些技术考虑因素和挑战。
证据水平
5 技术功效：第 3 阶段 J. 磁共振成像 2018;48:27-47.
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