Department of Chemistry , University of Copenhagen , Universitetsparken 5 , 2100 Copenhagen , Denmark.
Chem Rev. 2018 Sep 12;118(17):8285-8358. doi: 10.1021/acs.chemrev.8b00144. Epub 2018 Jul 3.
Catalytic glycosylation has been a central reaction in carbohydrate chemistry since its introduction by Fischer 125 years ago, but it is only in the past three to four decades that catalytic methods for synthesizing oligosaccharides have appeared. Despite the development of numerous elegant and ingenious catalytic glycosylation methods, only a few are in general use. This review covers all methods of catalytic glycosylation with the focus on the development and application in oligosaccharide synthesis and provide an overview of the scope and limitations of these. The review also includes relevant mechanistic studies of catalytic glycosylations. The future of catalytic glycosylation chemistry is discussed, including specific, upcoming methods and possible directions for the field of research in general.
催化糖基化自 125 年前 Fischer 引入以来一直是碳水化合物化学的核心反应，但直到过去三四十年，才出现了合成寡糖的催化方法。尽管已经开发出许多优雅而巧妙的催化糖基化方法，但只有少数几种方法得到广泛应用。本综述涵盖了所有催化糖基化方法，重点介绍了在寡糖合成中的发展和应用，并概述了这些方法的范围和局限性。该综述还包括催化糖基化的相关机理研究。还讨论了催化糖基化化学的未来，包括特定的、即将出现的方法以及该研究领域的可能方向。
