Siddique Yasir Hasan, Naz Falaq, Jyoti Smita, Ali Fahad
Drosophila Transgenic Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University , Aligarh , Uttar Pradesh , India.
J Diet Suppl. 2019;16(5):550-563. doi: 10.1080/19390211.2018.1472706. Epub 2018 Jul 3.
Parkinson's disease (PD) is the second-most common neurodegenerative disorder and is characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta. Oxidative stress has also been linked with the progression of PD, hence the involvement of a natural plant product could offer neuroprotection. The present study deals with the effect of genistein on the transgenic flies expressing normal human alpha synuclein panneurally. The PD flies were exposed to 10, 20, 30, and 40 µM of genistein (mixed in diet) for 24 days. A significant dose-dependent increase in the life span and delay in the loss of climbing ability were observed in the PD flies exposed to genistein ( < .05). A significant dose-dependent decrease in oxidative stress markers and increase in dopamine content were observed in PD flies exposed to genistein. However, the exposure of genistein did not inhibit the expression of α-synuclein in the brains of PD flies.
帕金森病（PD）是第二常见的神经退行性疾病，其特征是黑质致密部多巴胺能神经元的退化。氧化应激也与帕金森病的进展有关，因此天然植物产物的参与可能提供神经保护作用。本研究探讨了金雀异黄素对全神经元表达正常人α-突触核蛋白的转基因果蝇的影响。将帕金森病果蝇暴露于10、20、30和40微摩尔的金雀异黄素（混入食物中）24天。在暴露于金雀异黄素的帕金森病果蝇中观察到寿命显著剂量依赖性增加以及攀爬能力丧失延迟（P<0.05）。在暴露于金雀异黄素的帕金森病果蝇中观察到氧化应激标志物显著剂量依赖性降低以及多巴胺含量增加。然而，金雀异黄素的暴露并未抑制帕金森病果蝇大脑中α-突触核蛋白的表达。
