Pagella Pierfrancesco, de Vargas Roditi Laura, Stadlinger Bernd, Moor Andreas E, Mitsiadis Thimios A
Orofacial Development and Regeneration, Faculty of Medicine, Institute of Oral Biology, Center of Dental Medicine, University of Zurich, Plattenstrasse 11, 8032 Zurich, Switzerland.
Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland.
iScience. 2021 Apr 23;24(5):102405. doi: 10.1016/j.isci.2021.102405. eCollection 2021 May 21.
Teeth exert fundamental functions related to mastication and speech. Despite their great biomedical importance, an overall picture of their cellular and molecular composition is still missing. In this study, we have mapped the transcriptional landscape of the various cell populations that compose human teeth at single-cell resolution, and we analyzed in deeper detail their stem cell populations and their microenvironment. Our study identified great cellular heterogeneity in the dental pulp and the periodontium. Unexpectedly, we found that the molecular signatures of the stem cell populations were very similar, while their respective microenvironments strongly diverged. Our findings suggest that the microenvironmental specificity is a potential source for functional differences between highly similar stem cells located in the various tooth compartments and open new perspectives toward cell-based dental therapeutic approaches.
牙齿发挥着与咀嚼和言语相关的基本功能。尽管它们具有重大的生物医学重要性，但关于其细胞和分子组成的整体情况仍不明确。在本研究中，我们以单细胞分辨率绘制了构成人类牙齿的各种细胞群体的转录图谱，并更深入地分析了它们的干细胞群体及其微环境。我们的研究确定了牙髓和牙周组织中存在巨大的细胞异质性。出乎意料的是，我们发现干细胞群体的分子特征非常相似，而它们各自的微环境却有很大差异。我们的研究结果表明，微环境特异性是位于不同牙齿区域的高度相似干细胞之间功能差异的潜在来源，并为基于细胞的牙科治疗方法开辟了新的前景。
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