Shanghai Skin Disease Hospital, Tongji University Medical School, Shanghai, China.
Department of Dermatology, The PLA General Hospital of Air Force, Beijing, China.
Dermatology. 2018;234(1-2):43-50. doi: 10.1159/000489396. Epub 2018 Jul 3.
The ultraviolet-induced red fluorescence (UVRF) from human skin follicles was suggested to be a result of Propionibacterium acnes and was used for the monitoring of acne. More recent studies suggested that the UVRF may be more related to sebum rather than to microorganisms.
To clarify whether human sebum or follicular microorganisms are the source of UVRF.
We examined the fluorescence of human-derived SZ95 sebocytes, human sebaceous glands, sebum extracted from the sebaceous glands, and bacteria isolated from human hair follicles under ultraviolet light.
SZ95 sebocytes, human sebaceous glands, and sebum do not emit UVRF. Two types of UVRF peaking at about 635 nm and at about 620 nm were detected in P. acnes and Staphylococcus epidermidis, respectively. This is the first report that S. epidermidis emits UVRF when it is anaerobically cultured and then exposed to air.
Human follicular UVRF is emitted by resident bacteria, not by sebum. Therefore, UVRF may be used to monitor certain species of skin microorganisms.
人体皮肤毛囊的紫外线诱导红色荧光（UVRF）被认为是痤疮丙酸杆菌的结果，并被用于痤疮的监测。最近的研究表明，UVRF 可能与皮脂有关，而不是与微生物有关。
阐明 UVRF 的来源是人类皮脂还是毛囊微生物。
我们在紫外线照射下检查了人源性 SZ95 皮脂腺细胞、人皮脂腺、从皮脂腺中提取的皮脂以及从人毛囊中分离出的细菌的荧光。
SZ95 皮脂腺细胞、人皮脂腺和皮脂均不发出 UVRF。在痤疮丙酸杆菌和表皮葡萄球菌中分别检测到两种峰值约为 635nm 和 620nm 的 UVRF。这是首次报道表皮葡萄球菌在厌氧培养然后暴露于空气中时会发出 UVRF。
人体毛囊 UVRF 是由常驻细菌发出的，而不是皮脂。因此，UVRF 可用于监测某些皮肤微生物。
