Kim Hashin, Kim Hoon, Ku Seung-Yup
Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
Ann Pediatr Endocrinol Metab. 2018 Jun;23(2):70-74. doi: 10.6065/apem.2018.23.2.70. Epub 2018 Jun 20.
As the 5-year survival rate increases up to 80% in pediatric cancer patients, the number of women patients with reduced gonadal function by chemotherapy and radiotherapy increases. The gonadal toxicity of pediatric patients varies highly according to the chemotherapeutic agent and the type of radiotherapy. Although American Society of Clinical Oncology published the guideline for fertility preservation, additional scientific and ethical concerns should be considered for clinical practice. In addition, only the experimental method can be applied for the prepubertal patients in contrast to the postpubertal patients. In this review, we will discuss some options for preserving fertility among women's quality of life issues.
随着儿童癌症患者的5年生存率提高到80%，因化疗和放疗导致性腺功能减退的女性患者数量增加。儿童患者的性腺毒性因化疗药物和放疗类型的不同而有很大差异。尽管美国临床肿瘤学会发布了生育力保存指南，但临床实践中还应考虑其他科学和伦理问题。此外，与青春期后的患者相比，青春期前的患者只能采用实验性方法。在本综述中，我们将讨论在女性生活质量问题中保存生育力的一些选择。
