Kim Sung Woo, Kim Yoon Young, Kim Hoon, Ku Seung-Yup
Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, 03080, South Korea.
Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea.
Reprod Sci. 2021 Jun;28(6):1612-1625. doi: 10.1007/s43032-021-00553-y. Epub 2021 Apr 1.
Various gynecologic diseases and chemoradiation or surgery for the management of gynecologic malignancies may damage the uterus and ovaries, leading to clinical problems such as infertility or early menopause. Embryo or oocyte cryopreservation-the standard method for fertility preservation-is not a feasible option for patients who require urgent treatment because the procedure requires ovarian stimulation for at least several days. Hormone replacement therapy (HRT) for patients diagnosed with premature menopause is contraindicated for patients with estrogen-dependent tumors or a history of thrombosis. Furthermore, these methods cannot restore the function of the uterus and ovaries. Although autologous transplantation of cryopreserved ovarian tissue is being attempted, it may re-introduce malignant cells after cancer treatment. With the recent development in regenerative medicine, research on engineered biomaterials for the restoration of female reproductive organs is being actively conducted. The use of engineered biomaterials is a promising option in the field of reproductive medicine because it can overcome the limitations of current therapies. Here, we review the ideal properties of biomaterials for reproductive tissue engineering and the recent advancements in engineered biomaterials for the regeneration of female reproductive organs.
各种妇科疾病以及用于治疗妇科恶性肿瘤的放化疗或手术可能会损害子宫和卵巢，导致诸如不孕或过早绝经等临床问题。胚胎或卵母细胞冷冻保存——生育力保存的标准方法——对于需要紧急治疗的患者而言并非可行选择，因为该程序需要至少几天的卵巢刺激。对于被诊断为过早绝经的患者，激素替代疗法（HRT）对于患有雌激素依赖性肿瘤或有血栓形成病史的患者是禁忌的。此外，这些方法无法恢复子宫和卵巢的功能。尽管正在尝试冷冻保存卵巢组织的自体移植，但在癌症治疗后可能会再次引入恶性细胞。随着再生医学的最新发展，用于恢复女性生殖器官的工程生物材料的研究正在积极开展。工程生物材料的应用在生殖医学领域是一个有前景的选择，因为它可以克服当前疗法的局限性。在此，我们综述了用于生殖组织工程的生物材料的理想特性以及用于女性生殖器官再生的工程生物材料的最新进展。
