p53和Rb信号通路的改变与膀胱尿路上皮癌的高增殖相关。
Alterations of p53 and Rb Pathways Are Associated with High Proliferation in Bladder Urothelial Carcinomas.
作者信息
Goussia Anna C, Papoudou-Bai Alexandra, Charchanti Antonia, Kitsoulis Panagiotis, Kanavaros Panagiotis, Kalef-Ezra John, Stefanou Dimitrios, Agnantis Niki J
机构信息
Department of Pathology, Medical Faculty, School of Health Sciences, University of Ioannina, Ioannina, Greece
Department of Pathology, Medical Faculty, School of Health Sciences, University of Ioannina, Ioannina, Greece.
出版信息
Anticancer Res. 2018 Jul;38(7):3985-3988. doi: 10.21873/anticanres.12685.
BACKGROUND/AIM: Since most cancers are associated with alterations of the p53 and Rb pathways, the expression of p53, p21, Rb, p16, p27, cyclin D1, cyclin A, cyclin B1 and Ki67 proteins were analyzed in bladder urothelial carcinomas (BUC).
MATERIALS AND METHODS
One hundred twenty-two cases of BUC were studied by immunohistochemistry.
RESULTS
The pathways p53/p21 and Rb/p16/cyclin D1 exhibited alterations in 81/115 and 63/84 cases, respectively. Alterations of the p53/p21 and Rb/p16/cyclin D1 pathways were positively correlated with high cyclin A expression. High expression of p53, Ki67, cyclin A and cyclin B1 was inversely correlated with the papillary morphology of the tumor and positively with tumor grade and T-stage.
CONCLUSION
The results showed that a) alterations of the p53 and Rb pathways are associated with high proliferation of tumor cells in BUC and b) high expression of cell-cycle proteins is associated with adverse histopathological parameters of these tumors.
背景/目的：由于大多数癌症与p53和Rb信号通路的改变相关，因此对膀胱尿路上皮癌（BUC）中p53、p21、Rb、p16、p27、细胞周期蛋白D1、细胞周期蛋白A、细胞周期蛋白B1和Ki67蛋白的表达进行了分析。
材料与方法
采用免疫组织化学方法对122例BUC病例进行研究。
结果
p53/p21和Rb/p16/细胞周期蛋白D1信号通路分别在81/115例和63/84例中出现改变。p53/p21和Rb/p16/细胞周期蛋白D1信号通路的改变与细胞周期蛋白A的高表达呈正相关。p53、Ki67、细胞周期蛋白A和细胞周期蛋白B1的高表达与肿瘤的乳头状形态呈负相关，与肿瘤分级和T分期呈正相关。
结论
结果表明，a）p53和Rb信号通路的改变与BUC中肿瘤细胞的高增殖相关，b）细胞周期蛋白的高表达与这些肿瘤不良的组织病理学参数相关。
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