Lin Keng, Qiu Feng, Chen Shulin, He Xia, Peng Songguo, Chen Hao
The Maternal and Child Health Hospital of Huadu District, Guangzhou 510800, P.R. China.
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, P.R. China.
J Cancer Res Ther. 2018;14(4):785-788. doi: 10.4103/jcrt.JCRT_567_17.
Nasopharyngeal carcinoma (NPC) is endemic in Southern China and Southeast Asia. The ABO blood group antigens are chemical constituents on the surface of red blood cells and various epithelial cells. Several studies have described the association of ABO blood types with multiple types of human cancer. In this study, we aimed to investigate the relationship between the incidence of NPC and ABO blood groups.
We retrospectively analyzed the files of 1136 pathologically confirmed patients with NPC and 1024 cancer-free healthy controls, including the information of serologically determined blood group. The distribution of blood groups between patients with NPC and the control group was determined. The Chi-square test was applied to assess the distribution of age, gender, smoking, family history, and ABO blood groups between the NPC and the controls. Pearson's correlation was performed to evaluate the correlation between ABO blood groups and clinical stages.
There was no significant difference in age, smoking, family history, and ABO blood group between patients with NPC and the control group (P > 0.05). ABO blood groups were also not associated with NPC stages (P = 0.506). However, the proportion of males with NPC was higher than that of control group (P < 0.01).
The blood group types were not associated with increased risk of NPC and NPC stages in a population of Southern China.
鼻咽癌（NPC）在中国南方和东南亚地区呈地方性流行。ABO血型抗原是红细胞和各种上皮细胞表面的化学成分。多项研究描述了ABO血型与多种人类癌症的关联。在本研究中，我们旨在调查鼻咽癌发病率与ABO血型之间的关系。
我们回顾性分析了1136例经病理确诊的鼻咽癌患者和1024例无癌健康对照者的档案，包括血清学确定血型的信息。确定了鼻咽癌患者与对照组之间的血型分布。应用卡方检验评估鼻咽癌患者与对照组之间年龄、性别、吸烟、家族史和ABO血型的分布情况。采用Pearson相关性分析评估ABO血型与临床分期之间的相关性。
鼻咽癌患者与对照组在年龄、吸烟、家族史和ABO血型方面无显著差异（P>0.05）。ABO血型也与鼻咽癌分期无关（P = 0.506）。然而，鼻咽癌男性患者的比例高于对照组（P<0.01）。
在中国南方人群中，血型类型与鼻咽癌风险增加及鼻咽癌分期无关。
