Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing 210094, China.
Department of Physical Education, Nanjing University of Science & Technology, Nanjing 210094, China.
Nutrients. 2018 Jul 3;10(7):858. doi: 10.3390/nu10070858.
Fatigue induced by prolonged exercise not only leads to the decrease of exercise capacity, but also might be the cause of many diseases. In consideration of the side effects of pharmacological drugs, dietary supplements seem to be a better choice to ameliorate exercise-induced fatigue. The present study aimed to investigate the anti-fatigue effect of Salecan, a novel water-soluble -glucan, during exercise and explore the underlying mechanisms. Male Institute of Cancer Research (ICR) mice were divided into five groups, including the Rest group and the other four Swim-groups treated with Salecan at 0, 25, 50, and 100 mg/kg/day for four weeks. Salecan treatment markedly increased the exhaustive swimming time of mice in the forced swimming test. Exercise fatigue and injury-related biochemical biomarkers including lactate, blood urea nitrogen (BUN), creatinine kinase (CK), alanine transaminase (ALT), and aspartate transaminase (AST) were ameliorated by Salecan. Salecan reversed the decreased serum glucose levels and glycogen contents caused by exercise. In addition, Salecan improved oxidative stress induced by exercise through regulating Nrf2/HO⁻1/Trx signaling pathway. Thus, the beneficial effects of Salecan against fatigue may be due to its positive effects on energy metabolism and antioxidation defence. Our results suggest that Salecan could be a novel potential candidate for anti-fatigue dietary supplements.
长时间运动引起的疲劳不仅会导致运动能力下降，还可能是许多疾病的原因。考虑到药物的副作用，膳食补充剂似乎是改善运动性疲劳的更好选择。本研究旨在探讨新型水溶性 β-葡聚糖 Salecan 在运动中的抗疲劳作用，并探讨其潜在机制。雄性 ICR 小鼠分为 5 组，包括休息组和其他 4 组游泳组，分别用 0、25、50 和 100mg/kg/d 的 Salecan 处理 4 周。Salecan 处理明显延长了强迫游泳试验中小鼠的力竭游泳时间。Salecan 改善了运动性疲劳和损伤相关的生化生物标志物，包括乳酸、血尿素氮 (BUN)、肌酸激酶 (CK)、丙氨酸转氨酶 (ALT) 和天冬氨酸转氨酶 (AST)。Salecan 逆转了运动引起的血清葡萄糖水平和糖原含量降低。此外，Salecan 通过调节 Nrf2/HO-1/Trx 信号通路改善了运动引起的氧化应激。因此，Salecan 对疲劳的有益作用可能是由于其对能量代谢和抗氧化防御的积极影响。我们的结果表明，Salecan 可能是一种新型的抗疲劳膳食补充剂候选物。
