Muroya Masahiro, Nakada Kumiko, Maruo Kazushi, Hashimoto Koichi
Department of Clinical and Translational Research Methodology, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Department of Biostatistics, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Eur J Clin Nutr. 2025 Jan 28. doi: 10.1038/s41430-025-01567-4.
Several clinical trials suggest that β-glucans may reduce feelings of fatigue, however the results of clinical trials are inconsistent. Additionally, no systematic reviews or meta-analyses have assessed the effects of β-glucans on fatigue. Therefore, this study investigates the effects of β-glucans on fatigue in healthy subjects through a systematic review and meta-analysis. PubMed, Web of Science, and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched from database inception to March 15, 2024. The inclusion criterion was a randomized controlled trial (RCT) investigating the effects of β-glucans on healthy subjects' fatigue, vigor, and mood state. To assess risk of bias, we employed the Cochrane risk of bias tool. A random-effects meta-analysis was conducted for the standardized mean difference (SMD). Sixteen RCTs with a total of 1,449 participants were included, and 12 studies provided data suitable for meta-analysis. Meta-analysis revealed that β-glucans significantly reduced feelings of fatigue (SMD = -0.32, 95% CI = -0.53 to -0.12; p = 0.0021), increased vigor (SMD = 0.46, 95% CI = 0.26-0.66; p < 0.0001), and improved mood state (SMD = 0.32, 95% CI = 0.11-0.53; p = 0.0026) compared to the placebo group. The results of the systematic review and meta-analysis indicate that β-glucans may be effective in reducing feelings of fatigue in healthy individuals. However, the number of studies included is insufficient, suggesting that further clinical trials are needed to validate this effect.
多项临床试验表明，β-葡聚糖可能会减轻疲劳感，但临床试验结果并不一致。此外，尚无系统评价或荟萃分析评估β-葡聚糖对疲劳的影响。因此，本研究通过系统评价和荟萃分析来探究β-葡聚糖对健康受试者疲劳的影响。检索了PubMed、科学网和Cochrane对照试验中心注册库（CENTRAL），检索时间从数据库建立至2024年3月15日。纳入标准为一项随机对照试验（RCT），该试验探究β-葡聚糖对健康受试者疲劳、活力和情绪状态的影响。为评估偏倚风险，我们采用了Cochrane偏倚风险工具。对标准化均数差（SMD）进行随机效应荟萃分析。纳入了16项RCT，共1449名参与者，其中12项研究提供了适合荟萃分析的数据。荟萃分析显示，与安慰剂组相比，β-葡聚糖显著减轻了疲劳感（SMD = -0.32，95%CI = -0.53至-0.12；p = 0.0021），增加了活力（SMD = 0.46，95%CI = 0.26 - 0.66；p < 0.0001），并改善了情绪状态（SMD = 0.32，95%CI = 0.11 - 0.53；p = 0.0026）。系统评价和荟萃分析的结果表明，β-葡聚糖可能对减轻健康个体的疲劳感有效。然而，纳入的研究数量不足，这表明需要进一步的临床试验来验证这一效果。
