Nam So Jeong, Han You Jin, Lee Wonpyo, Kang Bitna, Choi Min-Koo, Han Yong-Hae, Song Im-Sook
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Korea.
College of Pharmacy, Dankook University, Cheon 31116, Korea.
Pharmaceutics. 2018 Jul 3;10(3):80. doi: 10.3390/pharmaceutics10030080.
The purpose of this study was to investigate the effect of red ginseng extract on the pharmacokinetics (PK) and efficacy of metformin in streptozotocin-induced diabetic rats. The diabetes mellitus rat model was established by intraperitoneally administering multiple doses of streptozotocin (30 mg/kg, twice on day 1 and 8), and diabetic rats received metformin 50 mg/kg with or without single or multiple administration of Korean red ginseng extract (RGE, 2 g/kg/day, once or for 1 week). RGE administration did not affect the plasma concentration and renal excretion of metformin. Further, diabetic rats were administered metformin (50 mg/kg) and RGE (2 g/kg) alone or concomitantly for 5 weeks, and both regimens decreased the fasting blood glucose and glycated hemoglobin (Hb-A1c) levels. Furthermore, fasting blood glucose levels were reduced by metformin or RGE administered alone but recovered to the control level following co-administration, suggesting that the effect was additive. However, triglyceride and free fatty acid levels were not different with metformin and RGE treatment alone or in combination. Biochemical parameters such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglycerides, total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol levels were not different among the three treatment groups. In conclusion, RGE and metformin showed an additive effect in glycemic control. However, the co-administration of RGE and metformin did not cause PK interactions or affect biochemical parameters including the free fatty acid, triglyceride, AST, ALT, or cholesterol levels.
本研究旨在探讨红参提取物对链脲佐菌素诱导的糖尿病大鼠体内二甲双胍的药代动力学（PK）及疗效的影响。通过腹腔注射多剂量链脲佐菌素（30 mg/kg，第1天和第8天各注射两次）建立糖尿病大鼠模型，糖尿病大鼠接受50 mg/kg二甲双胍治疗，同时单独或多次给予韩国红参提取物（RGE，2 g/kg/天，单次或连续1周）。给予RGE不影响二甲双胍的血浆浓度和肾排泄。此外，糖尿病大鼠单独或同时给予二甲双胍（50 mg/kg）和RGE（2 g/kg）持续5周，两种给药方案均降低了空腹血糖和糖化血红蛋白（Hb-A1c）水平。此外，单独给予二甲双胍或RGE可降低空腹血糖水平，但联合给药后恢复至对照水平，提示存在相加作用。然而，单独或联合使用二甲双胍和RGE治疗时，甘油三酯和游离脂肪酸水平并无差异。三个治疗组之间的丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、甘油三酯、总胆固醇、高密度脂蛋白（HDL）胆固醇、低密度脂蛋白（LDL）胆固醇等生化参数无差异。总之，RGE和二甲双胍在血糖控制方面显示出相加作用。然而，RGE与二甲双胍联合给药不会引起PK相互作用，也不会影响包括游离脂肪酸、甘油三酯、AST、ALT或胆固醇水平在内的生化参数。
