Mastroeni P, Bizzini B, Bonina L, Iannello D, Merendino R A, Delfino D, Berlinghieri M C, Leonardi M S, Arena A, Liberto M C
Immunopharmacology. 1985 Aug;10(1):27-34. doi: 10.1016/0162-3109(85)90056-6.
Many microorganisms and compounds of microbial origin exhibit immunomodulatory activities and have been extensively used in immunotherapy of experimental animal tumors and in patients with neoplasia. In this paper we describe the effect of the C. granulosum-derived P40 fraction on the growth and metastatization of the transplantable epithelioma T8 of Guèrin. Moreover, we evaluated the effect of P40 treatment on several depressed macrophage functions of tumor-bearing rats. In particular, the phagocytic and chemotactic activities of such cells were studied, as well as the antiviral intrinsic and extrinsic activities against HSV-1 and the anti-Toxoplasma gondii activity. All these functions were depressed in untreated tumor-bearing rats. Administration of a single intravenous injection of P40 fraction led to the restoration of all depressed macrophage activities to normal values. In particular, the possibility of restoring the antimicrobial activity of macrophages from tumor-bearing rats by treatment with this immunomodulator is of great concern when one considers the increasing incidence of opportunistic infections in immunocompromised hosts. Results are discussed in terms of both the possible mechanism of action of P40 and of its possible target cells.
许多微生物及源自微生物的化合物具有免疫调节活性，已被广泛应用于实验动物肿瘤的免疫治疗及肿瘤患者的治疗。在本文中，我们描述了颗粒丙酸杆菌衍生的P40组分对可移植的格林氏上皮瘤T8生长和转移的影响。此外，我们评估了P40处理对荷瘤大鼠几种受抑制的巨噬细胞功能的影响。特别研究了此类细胞的吞噬和趋化活性，以及针对单纯疱疹病毒1型的抗病毒内在和外在活性及抗弓形虫活性。在未经处理的荷瘤大鼠中，所有这些功能均受到抑制。单次静脉注射P40组分可使所有受抑制的巨噬细胞活性恢复至正常水平。特别是，考虑到免疫功能低下宿主中机会性感染的发生率不断增加，用这种免疫调节剂治疗恢复荷瘤大鼠巨噬细胞抗菌活性的可能性备受关注。本文从P40可能的作用机制及其可能的靶细胞方面对结果进行了讨论。
