可溶性肿瘤产物对正常大鼠巨噬细胞功能的抑制作用。细菌免疫调节剂全身治疗的效果。
Inhibition of normal rat macrophage functions by soluble tumor products. Effect of systemic treatment with bacterial immunomodulators.
作者信息
Iannello D, Bonina L, Delfino D, Berlinghieri M C, Mastroeni P
出版信息
Cancer Immunol Immunother. 1984;17(1):38-41. doi: 10.1007/BF00205495.
The phagocytic and chemotactic activities of normal rat peritoneal macrophages were inhibited by sera from tumor-bearing rats (TBR) and 3 M KCl extracts of tumor mass. However, sera from Corynebacterium parvum- or Listeria monocytogenes-treated TBR did not inhibit phagocytosis. On the other hand, sera from C. parvum-treated, but not from L. monocytogenes-treated TBR still inhibited the chemotactic response of the normal macrophages. Furthermore, 3 M KCl extracts of tumors from C. parvum-treated TBR did not inhibit phagocytosis and chemotactic response of the same cells. Similar results were obtained with extracts of tumor masses from L. monocytogenes-treated rats. It is suggested that treatment with bacterial immunomodulators can influence the release from neoplastic cells of soluble products influencing normal macrophage functions.
荷瘤大鼠（TBR）的血清以及肿瘤块的3M KCl提取物可抑制正常大鼠腹腔巨噬细胞的吞噬和趋化活性。然而，经短小棒状杆菌或单核细胞增多性李斯特菌处理的TBR血清并不抑制吞噬作用。另一方面，经短小棒状杆菌处理而非经单核细胞增多性李斯特菌处理的TBR血清仍可抑制正常巨噬细胞的趋化反应。此外，经短小棒状杆菌处理的TBR肿瘤的3M KCl提取物并不抑制相同细胞的吞噬和趋化反应。用经单核细胞增多性李斯特菌处理的大鼠的肿瘤块提取物也得到了类似结果。这表明用细菌免疫调节剂进行处理可影响肿瘤细胞释放影响正常巨噬细胞功能的可溶性产物。
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