Iannello D, Bonina L, Delfino D, Berlinghieri M C, Mastroeni P
Immunopharmacology. 1985 Jun;9(3):181-7. doi: 10.1016/0162-3109(85)90014-1.
In the present study, we compared the ability of different bacterial species administered orally in various combinations to restore some depressed peritoneal macrophage functions in tumor-bearing rats. Phagocytosis, killing of Candida albicans and chemotactic response of resident peritoneal cells from treated tumor-bearing rats were influenced by different associations of bacteria. In particular, when Staphylococcus aureus was administered together with other bacterial species, the phagocytic activity of peritoneal cells was restored to normal values, and intracellular killing of C. albicans was enhanced. The results are discussed in relation to the possible influence of mucosal bacterial flora on the level of activation of peritoneal macrophages. The possibility that bacterial species can influence in various ways immunocompetent cells in relation to the different chemical composition of some common structures is also discussed.
在本研究中，我们比较了以不同组合经口给予不同细菌种类后，其恢复荷瘤大鼠某些受抑制的腹腔巨噬细胞功能的能力。来自经处理的荷瘤大鼠的驻留腹腔细胞的吞噬作用、白色念珠菌杀伤能力及趋化反应受不同细菌组合的影响。特别是，当金黄色葡萄球菌与其他细菌种类一起给予时，腹腔细胞的吞噬活性恢复到正常水平，并且白色念珠菌的细胞内杀伤作用增强。结合黏膜细菌菌群对腹腔巨噬细胞激活水平的可能影响对结果进行了讨论。还讨论了细菌种类可能因其某些共同结构的不同化学组成而以多种方式影响免疫活性细胞的可能性。
