Karlstaedt Anja, Schiffer Walter, Taegtmeyer Heinrich
Division of Cardiology, Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, United States.
Front Cardiovasc Med. 2018 Jun 19;5:71. doi: 10.3389/fcvm.2018.00071. eCollection 2018.
Recent advances in cancer cell metabolism provide unprecedented opportunities for a new understanding of heart metabolism and may offer new approaches for the treatment of heart failure. Key questions driving the cancer field to understand how tumor cells reprogram metabolism and to benefit tumorigenesis are also applicable to the heart. Recent experimental and conceptual advances in cancer cell metabolism provide the cardiovascular field with the unique opportunity to target metabolism. This review compares cancer cell metabolism and cardiac metabolism with an emphasis on strategies of cellular adaptation, and how to exploit metabolic changes for therapeutic benefit.
癌细胞代谢的最新进展为重新认识心脏代谢提供了前所未有的机会,并可能为心力衰竭的治疗提供新方法。推动癌症领域去理解肿瘤细胞如何重新编程代谢以及如何促进肿瘤发生的关键问题同样适用于心脏。癌细胞代谢领域最近的实验和概念进展为心血管领域提供了靶向代谢的独特机会。本综述比较了癌细胞代谢和心脏代谢,重点关注细胞适应策略,以及如何利用代谢变化获得治疗益处。