Meng Fang, Gong Weijuan, Liao Yuexia, Xu Huiwen, Wang Xiao
School of Nursing, Yangzhou University, Yangzhou 225001, Jiangsu Province, China.
School of Nursing, Nanjing University of CM.
Zhongguo Zhen Jiu. 2018 Jun 12;38(6):575-9. doi: 10.13703/j.0255-2930.2018.06.002.
To compare the effect differences between auricular intradermal needling combined with erjian (HX) bloodletting and oral administration of western medicine, and to explore the efficacy of neuroendocrine level in patients with perimenopausal insomnia.
Ninety patients were randomized into an observation group and a control group, 45 cases in each one. In the observation group, auricular intradermal needling combined with erjian (HX) bloodletting were adopted alternately in the two ears. The auricular points were shen (CO), xin (CO), gan (CO), shenmen (TF), jiaogan (AH), neifenmi (CO) and erjian (HX). The treatment was required once 3 days on the auricular points of one side alternatively. Oral administration of estazolam (1mg each day) was applied in the control group for 2 courses, 4 weeks as 1 course, once a day. The scores of Pittsburgh sleep quality index (PSQI), the levels of serum estrogen (E), 5-hydroxy tryptamine (5-HT) and norepinephrine (NE) were valuated in the two groups before and after treatment.
After treatment, the total scores of PSQI reduced in the two groups (both <0.05), and the improvements of sleeping quality, sleeping time, sleeping difficulty, daytime dysfunction and the total PSQI score in the observation group were superior to those in the control group (all <0.05). There was no significant difference in serum E before and after treatment in the two groups，and between the two groups after treatment (all >0.05). After treatment, 5-HT contents increased and NE levels decreased in the two groups (all <0.05), with better results in the observation group (both <0.05). The total effective rate was 95.6% (43/45) in the observation group, which was higher than 82.2% (37/45) in the control group (<0.05).
Auricular intradermal needling combined with erjian (HX) bloodletting can improve the sleep quality of patients with perimenopausal insomnia, and adjust the neurotransmitter level, which achieves better effect than western medication.
比较耳穴皮内针联合耳尖（HX）放血与口服西药的疗效差异，探讨其对围绝经期失眠患者神经内分泌水平的影响。
将90例患者随机分为观察组和对照组，每组45例。观察组采用双耳交替耳穴皮内针联合耳尖（HX）放血治疗，耳穴取神门（CO）、心（CO）、肝（CO）、神门（TF）、交感（AH）、内分泌（CO）、耳尖（HX），一侧耳穴治疗3天1次，交替进行。对照组口服艾司唑仑（每天1mg），治疗2个疗程，4周为1个疗程，每天1次。分别于治疗前后评估两组患者匹兹堡睡眠质量指数（PSQI）评分、血清雌激素（E）、5-羟色胺（5-HT）及去甲肾上腺素（NE）水平。
治疗后，两组PSQI总分均降低（均P<0.05），且观察组睡眠质量、睡眠时间、入睡困难、日间功能障碍及PSQI总分改善情况均优于对照组（均P<0.05）。两组治疗前后血清E水平比较，差异无统计学意义，且两组治疗后比较，差异亦无统计学意义（均P>0.05）。治疗后，两组5-HT含量升高、NE水平降低（均P<0.05），且观察组改善情况优于对照组（均P<0.05）。观察组总有效率为95.6%（43/45），高于对照组的82.2%（37/45）（P<0.05）。
耳穴皮内针联合耳尖（HX）放血能改善围绝经期失眠患者睡眠质量，调节神经递质水平，疗效优于西药。
