Zou Rong, Tang Jun, Bao Shan, Wu Tian, Huang Jing-Lan, Qu Yi, Mu De-Zhi
Department of Pediatrics, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu 610041, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2018 Jun;20(6):449-455. doi: 10.7499/j.issn.1008-8830.2018.06.004.
To investigate the current status of the application of H-magnetic resonance spectroscopy (H-MRS) in neonates with hypoxic-ischemic encephalopathy (HIE), and to describe the trend of research in the field.
PubMed, EMBASE, and Web of Science were searched for English articles published up to January 10, 2018, with the combination of key words and MeSH terms. The articles were screened according to inclusion and exclusion criteria. Excel 2016, Bicomb 2.0, and VOSviewer1.6.6 were used to analyze the key words, to perform a cluster analysis of hot words, and to plot the knowledge map.
A total of 66 articles were included, and 27 high-frequency key words were extracted. The results showed that H-MRS was mainly used in four directions of the clinical practice and scientific research on HIE. In clinical practice, H-MRS attracted wide attention as a clinical examination for HIE and a tool for prognostic evaluation; in scientific research, H-MRS was used in animal experiments and studies associated with mild hypothermia therapy.
As an auxiliary means of magnetic resonance imaging, H-MRS plays an important role in investigating the pathogenesis of neonatal HIE, improving existing therapies, and evaluating the prognosis of neonates with HIE.
探讨氢磁共振波谱（H-MRS）在新生儿缺氧缺血性脑病（HIE）中的应用现状，并描述该领域的研究趋势。
检索PubMed、EMBASE和Web of Science数据库中截至2018年1月10日发表的英文文章，结合关键词和医学主题词进行检索。根据纳入和排除标准对文章进行筛选。使用Excel 2016、Bicomb 2.0和VOSviewer1.6.6对关键词进行分析，对热点词汇进行聚类分析，并绘制知识图谱。
共纳入66篇文章，提取出27个高频关键词。结果表明，H-MRS主要应用于HIE临床实践和科研的四个方向。在临床实践中，H-MRS作为HIE的临床检查手段和预后评估工具受到广泛关注；在科研方面，H-MRS用于动物实验以及与亚低温治疗相关的研究。
作为磁共振成像的辅助手段，H-MRS在探究新生儿HIE发病机制、改进现有治疗方法以及评估新生儿HIE预后方面发挥着重要作用。
