HIV阳性患者口腔念珠菌病的临床和实验室特征。
Clinical and laboratorial features of oral candidiasis in HIV-positive patients.
作者信息
Spalanzani Regiane Nogueira, Mattos Karine, Marques Luiza Inahe, Barros Pedro Fernando Diniz, Pereira Pamela Iruama Peres, Paniago Anamaria Mello Miranda, Mendes Rinaldo Poncio, Chang Marilene Rodrigues
机构信息
Curso de Farmácia, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brasil.
Programa de Pós-Graduação Stricto Sensu em Doenças Infecciosas e Parasitárias, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brasil.
出版信息
Rev Soc Bras Med Trop. 2018 May-Jun;51(3):352-356. doi: 10.1590/0037-8682-0241-2017.
INTRODUCTION
We describe the clinical and laboratorial features of oral candidiasis in 66 HIV-positive patients.
METHODS
Polymerase chain reaction-based techniques were performed for differentiation of Candida spp. isolated from patients at a public teaching hospital in Midwest Brazil.
RESULTS
Oral lesions, mainly pseudomembranous, were significantly related to higher levels of immunosuppression. Of 45 Candida isolates, 66.7% were C. albicans. Most of the isolates were susceptible to the antifungal drugs tested.
CONCLUSIONS
Oral lesions were associated with higher immunosuppression levels. Lower susceptibility to antifungals by non-albicans isolates supports the importance of surveillance studies using susceptibility tests to aid in the treatment.
引言
我们描述了66例HIV阳性患者口腔念珠菌病的临床和实验室特征。
方法
在巴西中西部一家公立教学医院，采用基于聚合酶链反应的技术对从患者分离出的念珠菌属进行鉴别。
结果
口腔病变主要为假膜性，与较高的免疫抑制水平显著相关。在45株念珠菌分离株中，66.7%为白色念珠菌。大多数分离株对所测试的抗真菌药物敏感。
结论
口腔病变与较高的免疫抑制水平相关。非白色念珠菌分离株对抗真菌药物较低的敏感性支持了利用药敏试验进行监测研究以辅助治疗的重要性。
Zotero 插件