Liu Chun-Lin, Lin Ming-Yen, Hwang Shang-Jyh, Liu Ching-Kuan, Lee Huei-Lan, Wu Ming-Tsang
Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Road, Kaohsiung, 80708, Taiwan.
Calo Psychiatric Center, No.12-200, Jinhua Rd., Xinpi Township, Pingtung County, 925, Taiwan.
BMC Endocr Disord. 2018 Jul 4;18(1):45. doi: 10.1186/s12902-018-0273-z.
Incidence of dementia is growing rapidly and affects many people worldwide. Type 2 diabetes mellitus (DM) might link cognitive decline and dementia, but the reasons for this association remain unclear. Our study explored the factors associated with type 2 DM in patients with dementia.
Patients (n = 40,404) with vascular dementia were identified in Taiwan's 1997 to 2008 National Health Insurance Research Database and divided into a DM group and non-DM group. Eleven comorbidities were identified and categorized into four groups: cardiovascular and cerebrovascular diseases, digestive system diseases, renal and metabolic system diseases, and cancer. The associations of these factors with type 2 DM were explored through multivaraible logistic regression.
Of the patients with dementia, 22.5% had DM. Associated with a higher likelihood of DM in this population were female sex (adjusted odds ratio [OR]: 1.44, 95% confidence interval [CI]: 1.36-1.52), young age (range of adjusted OR: 0.55-1.13), low income (range of adjusted OR: 1.09-1.18), and renal and metabolic system diseases (OR: 2.81, 95% CI: 2.64-2.98).
The findings of this study suggest that clinicians should encourage patients with dementia to receive regular glucose impairment screening if they are female, have low socioeconomic status, or have renal or metabolic diseases.
痴呆症的发病率正在迅速上升，影响着全球许多人。2型糖尿病（DM）可能与认知能力下降和痴呆症有关，但这种关联的原因尚不清楚。我们的研究探讨了痴呆症患者中与2型糖尿病相关的因素。
在台湾1997年至2008年的国民健康保险研究数据库中识别出血管性痴呆患者（n = 40404），并将其分为糖尿病组和非糖尿病组。确定了11种合并症，并将其分为四组：心血管和脑血管疾病、消化系统疾病、肾脏和代谢系统疾病以及癌症。通过多变量逻辑回归探讨这些因素与2型糖尿病的关联。
在痴呆症患者中，22.5%患有糖尿病。在该人群中，女性（调整后的优势比[OR]：1.44，95%置信区间[CI]：1.36 - 1.52）、年轻（调整后的OR范围：0.55 - 1.13）、低收入（调整后的OR范围：1.09 - 1.18）以及肾脏和代谢系统疾病（OR：2.81，95% CI：2.64 - 2.98）与患糖尿病的可能性较高相关。
本研究结果表明，临床医生应鼓励患有痴呆症的女性、社会经济地位较低或患有肾脏或代谢疾病的患者接受定期的血糖损害筛查。
