Akia Mandana, Salinas Nataly, Rodriguez Cristobal, Gilkerson Robert, Materon Luis, Lozano Karen
Department of Mechanical Engineering, University of Texas Rio Grande Valley, Edinburg, TX 78539, USA.
Department of Biology, University of Texas Rio Grande Valley, Edinburg, TX 78539, USA.
Membranes (Basel). 2018 Jul 4;8(3):38. doi: 10.3390/membranes8030038.
Fine fibers of polyhydroxybutyrate (PHB), a biopolymer, were developed via a centrifugal spinning technique. The developed fibers have an average diameter of 1.8 µm. Texas sour orange juice (SOJ) was applied as a natural antibacterial agent and infiltrated within the fibrous membranes. The antibacterial activity against common Gram-positive and Gram-negative bacteria ( and , respectively) was evaluated as well as cell adhesion and viability. The PHB/SOJ scaffolds showed antibacterial activity of up to 152% and 71% against and , respectively. The cell studies revealed a suitable environment for cell growth and cell attachment. The outcome of this study opens up new opportunities for fabrication of fibrous materials for biomedical applications having multifunctional properties while using natural agents.
通过离心纺丝技术制备了生物聚合物聚羟基丁酸酯（PHB）的细纤维。所制备的纤维平均直径为1.8微米。将德州酸橙汁（SOJ）用作天然抗菌剂并渗透到纤维膜中。评估了对常见革兰氏阳性菌和革兰氏阴性菌（分别为和）的抗菌活性以及细胞粘附和活力。PHB/SOJ支架对和的抗菌活性分别高达152%和71%。细胞研究表明其为细胞生长和细胞附着提供了适宜的环境。本研究结果为利用天然试剂制备具有多功能特性的生物医学应用纤维材料开辟了新机遇。
