CICS-UBI - Centro de Investigação em Ciências da Saúde, Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, Portugal.
CICS-UBI - Centro de Investigação em Ciências da Saúde, Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, Portugal; UDI-IPG- Unidade de Investigação para o Desenvolvimento do Interior, Instituto Politécnico da Guarda, 6300-559 Guarda, Portugal.
Eur J Pharm Biopharm. 2018 Jun;127:130-141. doi: 10.1016/j.ejpb.2018.02.022. Epub 2018 Feb 17.
Skin and soft tissue infections (SSTIs) have high rates of morbidity and mortality associated. Despite the successful treatment of some SSTIs, those affecting the subcutaneous tissue, fascia, or muscle delay the healing process and can lead to life-threatening conditions. Therefore, more effective treatments are required to deal with such pathological situations. Recently, wound dressings loaded with antimicrobial agents emerged as viable options to reduce wound bacterial colonization and infection, in order to improve the healing process. In this review, an overview of the most prominent antibacterial agents incorporated in wound dressings along with their mode of action is provided. Furthermore, the recent advances in the therapeutic approaches used in the clinic and some future perspectives regarding antibacterial wound dressings are also discussed.
皮肤和软组织感染（SSTIs）与高发病率和死亡率相关。尽管一些 SSTIs 的治疗取得了成功，但那些影响皮下组织、筋膜或肌肉的 SSTIs 会延迟愈合过程，并可能导致危及生命的情况。因此，需要更有效的治疗方法来处理这种病理情况。最近，载有抗菌剂的伤口敷料作为减少伤口细菌定植和感染的可行选择出现了，以改善愈合过程。在这篇综述中，概述了载于伤口敷料中的最突出的抗菌剂及其作用模式。此外，还讨论了临床中使用的治疗方法的最新进展以及抗菌伤口敷料的一些未来展望。
