Krishnamurthy Jagadeesh, Naragund Adithya V, Mahadevappa Basant
Department of HPB surgery & Liver Transplantation, HCG Hospital, Bengaluru, 560027 India.
Indian J Surg. 2018 Jun;80(3):269-271. doi: 10.1007/s12262-017-1713-0. Epub 2017 Dec 21.
Twenty five percent of total liver volume (TLV) is considered as the ideal functional liver remnant (FLR) in major liver resections. In patients with macro-vesicular steatosis, early cirrhosis, and post-neoadjuvant chemotherapy (NACT), hepatocellular injury is common. In such instances, up to 40% of FLR may be required. So in cases of marginal FLR, pre-operative portal vein (PV) embolization or two-stage hepatectomy with PV occlusion is used. Both of which take up to 14 weeks between stages and 30% of patients fail to reach the second resection either due to inadequate FLR growth or disease progression. Associated liver partition and portal vein ligation (ALPPS) procedure has become the gold standard for those cases. A 57-year-old male presented with rectosigmoid growth + multiple right liver and segment 4B metastases. Post-NACT MRI showed interval progression of lesions. Preoperative CT (computed tomography) volumetric scan showed a FLR/TLV (future liver remnant/total liver volume) of 22%. Since patient received 10 cycles of NACT, ALPPS procedure was planned ahead of direct liver resection. Robotic ALPPS stage 1 sparing left lateral segment and 4A + anterior resection was done. We transected the parenchyma between the FLR and the diseased part of the liver with concomitant right portal vein ligation done robotically. CT abdomen done on POD7 showed hypertrophied left lateral segment. Second stage was performed on the eighth post-operative day with FLR/TLV increasing to 37%. Robotic ALPPS procedure for stage one is a safe and feasible technique in experienced centers with advanced robotic skills.
在主要肝脏切除术中,25%的全肝体积(TLV)被视为理想的功能性肝剩余(FLR)。在患有大泡性脂肪变性、早期肝硬化和新辅助化疗(NACT)后的患者中,肝细胞损伤很常见。在这种情况下,可能需要高达40%的FLR。因此,在FLR处于临界状态的病例中,可采用术前门静脉(PV)栓塞或PV闭塞的两阶段肝切除术。这两种方法在两个阶段之间都需要长达14周的时间,并且30%的患者由于FLR生长不足或疾病进展而未能进行第二次切除。联合肝脏分隔和门静脉结扎(ALPPS)手术已成为这些病例的金标准。一名57岁男性患者出现直肠乙状结肠肿物+多发右肝及4B段转移。NACT后MRI显示病变有进展。术前CT(计算机断层扫描)容积扫描显示FLR/TLV(未来肝剩余/全肝体积)为22%。由于患者接受了10个周期的NACT,因此计划在直接肝切除术前进行ALPPS手术。进行了机器人辅助的ALPPS第一阶段手术,保留左外侧段和4A段并进行前切除术。我们通过机器人辅助同时结扎右门静脉,横断了FLR与肝脏病变部分之间的实质。术后第7天进行的腹部CT显示左外侧段肥大。第二阶段手术在术后第8天进行,此时FLR/TLV增加到37%。对于有经验的具备先进机器人技术的中心来说,机器人辅助的ALPPS第一阶段手术是一种安全可行的技术。