Murugesan Suriya Narayanan, Yadav Birendra Singh, Maurya Pramod Kumar, Chaudhary Amit, Singh Swati, Mani Ashutosh
Department of Biotechnology, Motilal Nehru National Institute of Technology, Allahabad, India-211004.
Center of Bioinformatics, University of Allahabad, India-211002.
J Genomics. 2018 Jun 26;6:103-112. doi: 10.7150/jgen.20581. eCollection 2018.
Y-Box Binding protein 1 (YBX-1) is known to be involved in various types of cancers. It's interactors also play major role in various cellular functions. Present work aimed to study the expression profile of the YBX-1 interactors during lung adenocarcinoma (LUAD). The differential expression analysis involved 57 genes from 95 lung adenocarcinoma samples, construction of gene network and topology analysis. A Total of 43 genes were found to be differentially expressed from which 17 genes were found to be down regulated and 26 genes were up-regulated. We observed that Polyadenylate-binding protein 1 (PABPC1), a protein involved in YBX1 translation, is highly correlated with YBX1. The interaction network analysis for a differentially expressed non-coding RNA Growth Arrest Specific 5 (GAS5) suggests that two proteins namely, Growth Arrest Specific 2 (GAS2) and Peripheral myelin protein 22 (PMP22) are potentially involved in LUAD progression. The network analysis and differential expression suggests that Collagen type 1 alpha 2 (COL1A2) can be potential biomarker and target for LUAD.
Y盒结合蛋白1（YBX - 1）已知与多种类型的癌症有关。其相互作用蛋白在各种细胞功能中也起着重要作用。目前的工作旨在研究YBX - 1相互作用蛋白在肺腺癌（LUAD）中的表达谱。差异表达分析涉及95个肺腺癌样本中的57个基因，构建基因网络并进行拓扑分析。共发现43个基因存在差异表达，其中17个基因下调，26个基因上调。我们观察到参与YBX1翻译的聚腺苷酸结合蛋白1（PABPC1）与YBX1高度相关。对差异表达的非编码RNA生长停滞特异性5（GAS5）的相互作用网络分析表明，生长停滞特异性2（GAS2）和外周髓鞘蛋白22（PMP22）这两种蛋白可能参与LUAD进展。网络分析和差异表达表明，Ⅰ型胶原α2链（COL1A2）可能是LUAD的潜在生物标志物和靶点。
