糖尿病微血管病变中的 RNA 结合蛋白。
RNA-binding proteins in diabetic microangiopathy.
机构信息
Department of Internal Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, China.
出版信息
J Clin Lab Anal. 2022 May;36(5):e24407. doi: 10.1002/jcla.24407. Epub 2022 Apr 6.
BACKGROUND
As the most common complication of diabetes, the diabetic microangiopathy characterizes diabetic retinopathy (DR) and nephropathy (DN). Diabetic microangiopathy has always been a serious clinical problem. A wide variety of nucleic acid interacting factors called the RNA binding proteins (RBPS) take part in several crucial cellular processes.
METHODS
Over the past decade, studies have shown that RBPs have crucial part in both malignant tumors and diabetes, especially in diabetic microangiopathy. This review examined the research history of RBPS in DR and DN.
RESULTS
We reviewed the literature and found that RBPS is potentially useful as therapeutic targets, diagnostic markers, or predict disease progression.
CONCLUSION
HuR acts as a vital therapeutic targeting protein in diabetic microangiopathy. IGF2BP2, P311, TTP, YBX1, and MBNL1 have a potential role in the treatment of DN.
背景
作为糖尿病最常见的并发症，糖尿病微血管病变的特征是糖尿病视网膜病变（DR）和糖尿病肾病（DN）。糖尿病微血管病变一直是一个严重的临床问题。大量被称为 RNA 结合蛋白（RBPS）的核酸相互作用因子参与了几个关键的细胞过程。
方法
在过去的十年中，研究表明 RBPS 在恶性肿瘤和糖尿病中，特别是在糖尿病微血管病变中，起着至关重要的作用。本综述探讨了 RBPS 在 DR 和 DN 中的研究历史。
结果
我们查阅了文献，发现 RBPS 作为治疗靶点、诊断标志物或预测疾病进展具有潜在的应用价值。
结论
HuR 作为糖尿病微血管病变的重要治疗靶点蛋白。IGF2BP2、P311、TTP、YBX1 和 MBNL1 在治疗 DN 中具有潜在作用。
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