Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK.
Invicro London, London, UK.
J Clin Endocrinol Metab. 2021 Mar 25;106(4):e1837-e1848. doi: 10.1210/clinem/dgaa746.
The hormone kisspeptin has crucial and well-characterized roles in reproduction. Emerging data from animal models also suggest that kisspeptin has important metabolic effects including modulation of food intake. However, to date there have been no studies exploring the effects of kisspeptin on brain responses to food stimuli in humans.
This work aims to investigate the effects of kisspeptin administration on brain responses to visual food stimuli and psychometric parameters of appetite, in healthy men.
A double-blinded, randomized, placebo-controlled, crossover study was conducted.
Participants included 27 healthy, right-handed, eugonadal men (mean ± SEM: age 26.5 ± 1.1 years; body mass index 23.9 ± 0.4 kg/m2).
Participants received an intravenous infusion of 1 nmol/kg/h of kisspeptin or rate-matched vehicle over 75 minutes.
Measurements included change in brain activity on functional magnetic resonance imaging in response to visual food stimuli and change in psychometric parameters of appetite, during kisspeptin administration compared to vehicle.
Kisspeptin administration at a bioactive dose did not affect brain responses to visual food stimuli or psychometric parameters of appetite compared to vehicle.
This is the first study in humans investigating the effects of kisspeptin on brain regions regulating appetite and demonstrates that peripheral administration of kisspeptin does not alter brain responses to visual food stimuli or psychometric parameters of appetite in healthy men. These data provide key translational insights to further our understanding of the interaction between reproduction and metabolism.
激素 kisspeptin 在生殖方面具有关键且特征明确的作用。来自动物模型的新数据也表明，kisspeptin 对代谢有重要影响，包括调节食物摄入。然而，迄今为止，尚无研究探讨 kisspeptin 对人类大脑对食物刺激的反应的影响。
本研究旨在探讨 kisspeptin 给药对健康男性大脑对视觉食物刺激的反应以及食欲的心理测量参数的影响。
进行了一项双盲、随机、安慰剂对照、交叉研究。
参与者包括 27 名健康、右利手、正常生育力的男性（平均±SEM：年龄 26.5±1.1 岁；体重指数 23.9±0.4kg/m2）。
参与者接受 1nmol/kg/h 的 kisspeptin 或速率匹配的载体静脉输注，持续 75 分钟。
测量包括在 kisspeptin 给药期间与载体相比，视觉食物刺激对功能磁共振成像的大脑活动变化以及食欲的心理测量参数的变化。
与载体相比，生物活性剂量的 kisspeptin 给药不会影响大脑对视觉食物刺激的反应或食欲的心理测量参数。
这是在人类中首次研究 kisspeptin 对调节食欲的大脑区域的影响的研究，表明外周给予 kisspeptin 不会改变健康男性大脑对视觉食物刺激或食欲的心理测量参数的反应。这些数据为进一步了解生殖与代谢之间的相互作用提供了关键的转化见解。
