内脏脂肪过多会增加患乳腺癌的风险：一项病例对照研究。

Visceral adiposity increases the risk of breast cancer: a case-control study.

作者信息

Godinho-Mota Jordana Carolina Marques, Martins Karine Anusca, Vaz-Gonçalves Larissa, Mota João Felipe, Soares Leonardo Ribeiro, Freitas-Junior Ruffo

机构信息

Federal University of Goias.

出版信息

Nutr Hosp. 2018 Jun 10;35(3):576-581. doi: 10.20960/nh.1441.

DOI:10.20960/nh.1441

PMID:29974765

Abstract

INTRODUCTION

in recent decades, lifestyle changes in women involving physical inactivity, insulin resistance and body fat distribution have been associated with an increase in breast cancer.

OBJECTIVE

to assess whether insulin resistance, lipid profile, and visceral adiposity are associated with increased risk of breast cancer.

METHODS

a hospital-based case control study was conducted with 116 women newly diagnosed with breast cancer and 226 controls. Body mass index, waist circumference, total cholesterol, high-density lipoproteins (HDL), low-density lipoproteins (LDL), very-low-density lipoproteins (VLDL), triglycerides, glycated hemoglobin, HOMA-IR, HOMA-β, lipid accumulation product (LAP), and visceral adiposity index (VAI) were assessed. Logistic regression was adjusted for body mass index and age to quantify the association between breast cancer risk and insulinresistance, dyslipidemias, and visceral adiposity.

RESULTS

the case group had higher insulin resistance (p < 0.001), LAP (p = 0.012), and VAI (p = 0.004), and lower concentrations of HDL (p = 0.024) and HOMA-β(p = 0.010) compared to the control. Insulin resistance (OR = 3.00, 95% CI: 1.75-5.17, p < 0.001) and higher VAI (OR = 1.91, 95% CI: 1.17-3.13, p = 0.01) were associated with breast cancer, whereas the highest concentration of HDL reduces the chances of cancer by 53% (95% CI: 0.32-0.86, p = 0.026). In the multivariate analysis, only LAP and VAI were associated to breast cancer.

CONCLUSIONS

visceral fat accumulation increases the risk of breast cancer.

摘要

引言

近几十年来，女性生活方式的改变，包括缺乏身体活动、胰岛素抵抗和体脂分布，与乳腺癌发病率的增加有关。

目的

评估胰岛素抵抗、血脂谱和内脏肥胖是否与乳腺癌风险增加相关。

方法

进行了一项基于医院的病例对照研究，研究对象为116名新诊断为乳腺癌的女性和226名对照。评估了体重指数、腰围、总胆固醇、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、极低密度脂蛋白（VLDL）、甘油三酯、糖化血红蛋白、HOMA-IR、HOMA-β、脂质蓄积产物（LAP）和内脏肥胖指数（VAI）。对体重指数和年龄进行逻辑回归调整，以量化乳腺癌风险与胰岛素抵抗、血脂异常和内脏肥胖之间的关联。

结果

与对照组相比，病例组具有更高的胰岛素抵抗（p < 0.001）、LAP（p = 0.012）和VAI（p = 0.004），以及更低的HDL浓度（p = 0.024）和HOMA-β（p = 0.010）。胰岛素抵抗（OR = 3.00，95%CI：1.75 - 5.17，p < 0.001）和更高的VAI（OR = 1.91，95%CI：1.17 - 3.13，p = 0.01）与乳腺癌相关，而HDL的最高浓度可使患癌几率降低53%（95%CI：0.32 - 0.86，p = 0.026）。在多变量分析中，只有LAP和VAI与乳腺癌相关。