Ismi O, Kara T, Polat G, Bobusoglu O, Vayısoglu Y, Gorur K, Ozcan C
Department of Otorhinolaryngology,University of Mersin,Turkey.
Department of Pathology,University of Mersin,Turkey.
J Laryngol Otol. 2018 Aug;132(8):724-728. doi: 10.1017/S0022215118000981. Epub 2018 Jul 5.
Although the role of neurotrophins such as nerve growth factor and brain-derived neurotrophic factor in nasal polyps development has been studied, the contribution of neurotrophin-3 has not been evaluated yet. This study aimed to investigate the possible role of neurotrophin-3 in nasal polyps pathogenesis.
The study group comprised 70 non-allergic nasal polyps patients and the control group consisted of 53 patients with middle turbinate concha bullosa. Specimens were taken, during surgery, from the ethmoid sinus nasal polyps in the nasal polyps group and from the lateral part of the middle turbinate concha bullosa in the control group. Tissue and serum levels of neurotrophin-3 were assessed by immunohistochemistry and enzyme-linked immunosorbent assay, respectively.
Nasal polyps patients had higher tissue neurotrophin-3 scores (p < 0.001). There was no statistically significant difference between groups regarding serum neurotrophin-3 levels (p = 0.417). Tissue neurotrophin-3 staining scores in the nasal polyps group had no statistically significant correlation with Lund-Mackay scores (p = 0.792).
Neurotrophin-3 may have a local effect in nasal polyps pathogenesis, without joining systemic circulation.
尽管已经研究了神经生长因子和脑源性神经营养因子等神经营养素在鼻息肉形成中的作用，但神经营养素-3的作用尚未得到评估。本研究旨在探讨神经营养素-3在鼻息肉发病机制中的可能作用。
研究组包括70例非过敏性鼻息肉患者，对照组由53例中鼻甲泡状鼻甲患者组成。在手术过程中，从鼻息肉组的筛窦鼻息肉和对照组的中鼻甲泡状鼻甲外侧取材。分别通过免疫组织化学和酶联免疫吸附测定法评估神经营养素-3的组织和血清水平。
鼻息肉患者的组织神经营养素-3评分较高（p < 0.001）。两组血清神经营养素-3水平无统计学显著差异（p = 0.417）。鼻息肉组的组织神经营养素-3染色评分与Lund-Mackay评分无统计学显著相关性（p = 0.792）。
神经营养素-3可能在鼻息肉发病机制中具有局部作用，而不参与体循环。
