Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zürich, Vladimir Prelog Weg 1, 8093, Zürich, Switzerland.
Department of Bionano Engineering, Hanyang University, Ansan, 15588, South Korea.
Chemistry. 2018 Aug 14;24(46):12078-12083. doi: 10.1002/chem.201802750. Epub 2018 Jul 24.
In recent years there has been huge interest in the development of microfluidic reactors for the synthesis of small molecules and nanomaterials. Such reaction platforms represent a powerful and versatile alternative to traditional formats since they allow for the precise, controlled, and flexible management of reactive processes. To date, the majority of microfluidic reactors used in small-molecule synthesis have been manufactured using conventional lithographic techniques from materials such as glasses, ceramics, stainless steel, and silicon. Surprisingly, the fabrication of microfluidic devices from such rigid materials remains ill-defined, complex, and expensive. Accordingly, the microfluidic toolkit for chemical synthesis would significantly benefit from the development of solvent-resistant microfluidic devices that can be manufactured using soft-lithographic prototyping methods. Whilst significant advances in the development of solvent-resistant polymers have been made, only modest steps have been taken towards simplifying their use as microfluidic reactors. Herein, we emphasize the benefits of using a commercially available, amorphous perfluorinated polymer, CYTOP, as a coating with which to transform PDMS into a chemically inert material for use in organic synthesis applications. Its efficacy is demonstrated through the subsequent performance of photooxidation reactions and reactions under extremely acidic or basic conditions.
近年来，人们对用于小分子和纳米材料合成的微流控反应器的开发产生了浓厚的兴趣。与传统形式相比，这些反应平台代表了一种强大且多功能的替代方案，因为它们允许对反应过程进行精确、可控和灵活的管理。迄今为止，在小分子合成中使用的大多数微流控反应器都是使用玻璃、陶瓷、不锈钢和硅等材料的传统光刻技术制造的。令人惊讶的是，由这些刚性材料制造微流控器件的方法仍然定义不明确、复杂且昂贵。因此，化学合成的微流控工具包将非常受益于溶剂抗性微流控器件的开发，这些器件可以使用软光刻原型制作方法制造。尽管在开发耐溶剂聚合物方面取得了重大进展，但在简化其作为微流控反应器的使用方面仅取得了适度的进展。在这里，我们强调了使用市售的无定形全氟聚合物 CYTOP 作为涂层的优势，该涂层可将 PDMS 转化为用于有机合成应用的化学惰性材料。通过随后进行的光氧化反应和在极酸或极碱性条件下的反应证明了其功效。
