Department of Biology and Chemistry, Azusa Pacific University, Azusa, CA, USA.
Graduate Institute of Microbiology and Public Health, National Chung Hsing University, Taichung, Taiwan.
J Food Drug Anal. 2018 Jul;26(3):1015-1023. doi: 10.1016/j.jfda.2017.12.006. Epub 2018 Feb 2.
Curcumin (Cur), a polyphenolic compound extracted from spice and common food colourant turmeric, contains versatile bio-activities. Monoacetylcurcumin (MAC), a structural analogue of Cur, differs from Cur by acetyl modification, but retains enone groups. Comparative analysis revealed MAC effectively inhibited influenza virus infection (IAV) to a similar extent as, if not superior to, curcumin. Both compounds mildly reduced viral NA activity. Surprisingly, unlike Cur, the MAC inhibition of IAV did not occur through the blocking of HA activity. However, MAC strongly dampened Akt phosphorylation, the prerequisite signalling for efficient IAV propagation. A much stronger inhibition effect on IAV infection was observed when MAC treatment was in combination with Cur. Collectively, MAC demonstrated clear antiviral activity, and likely inhibited IAV via multiple mechanisms that were not identical to Cur. Importantly, Cur and MAC in combination synergistically inhibited IAV infection.
姜黄素（Cur）是从香料和常见食用色素姜黄中提取的多酚化合物，具有多种生物活性。单乙酰基姜黄素（MAC）是姜黄素的结构类似物，通过乙酰化修饰与 Cur 不同，但保留了烯酮基团。比较分析表明，MAC 能有效抑制流感病毒感染（IAV），其效果与姜黄素相似，甚至优于姜黄素。这两种化合物都能轻微降低病毒 NA 的活性。令人惊讶的是，与 Cur 不同，MAC 对 IAV 的抑制作用并非通过阻止 HA 活性来实现。然而，MAC 强烈抑制 Akt 磷酸化，这是 IAV 有效传播的必要信号。当 MAC 治疗与 Cur 联合使用时，对 IAV 感染的抑制作用更强。总的来说，MAC 表现出明显的抗病毒活性，可能通过与 Cur 不同的多种机制抑制 IAV。重要的是，Cur 和 MAC 联合使用具有协同抑制 IAV 感染的作用。
