Mahat Roshan Kumar, Singh Neelima, Rathore Vedika, Gupta Akshara, Shah Rakesh Kumar
Department of Biochemistry, Gajra Raja Medical College, Gwalior 474009, India.
Department of Radiodiagnosis, Gajra Raja Medical College, Gwalior 474009, India.
Med Sci (Basel). 2018 Jul 5;6(3):55. doi: 10.3390/medsci6030055.
Prediabetes is the precursor stage of diabetes mellitus and is also considered to be a risk factor for the development of cardiovascular disease. Atherogenic indices have been used for assessment of risk for cardiovascular disease development. To date, there is no data on evaluating the relationship between atherogenic indices (cardiac risk ratio (CRR), atherogenic coefficient (AC), and atherogenic index of plasma (AIP)) and carotid intima-media thickness (CIMT) in prediabetes. Hence, we aimed to determine atherogenic indices (CRR, AC, and AIP) and CIMT in prediabetic subjects and then sought to evaluate the relationship between them. A total of 400 human subjects were included in the present study, out of which 200 were prediabetic subjects and 200 were normal healthy control subjects. For each subject, CRR, AC, and AIP were calculated from routine lipid parameters and carotid intima-media thickness was measured as well. Atherogenic indices, that is, CRR, AC, and AIP, were significantly increased in prediabetic subjects as compared to the controls (5.87 ± 0.87 vs. 4.23 ± 0.50, < 0.001; 4.87 ± 0.87 vs. 3.23 ± 0.50, < 0.001; and 0.29 ± 0.07 vs. 0.09 ± 0.09, < 0.001, respectively). Moreover, a significant and positive correlation was observed between CIMT and AIP ( = 0.529, < 0.01), CRR ( = 0.495, < 0.01), and AC ( = 0.495, < 0.01). Prediabetic subjects present abnormalities in atherogenic indices and CIMT, which indicate a greater propensity of prediabetes for the development of cardiovascular disease. Hence, atherogenic indices can be used in addition to routine lipid parameters for the better assessment of subclinical atherosclerosis in prediabetic subjects.
糖尿病前期是糖尿病的前驱阶段，也被认为是心血管疾病发生发展的一个危险因素。致动脉粥样硬化指数已被用于评估心血管疾病发生的风险。迄今为止，尚无关于评估糖尿病前期患者致动脉粥样硬化指数（心脏风险比（CRR）、致动脉粥样硬化系数（AC）和血浆致动脉粥样硬化指数（AIP））与颈动脉内膜中层厚度（CIMT）之间关系的数据。因此，我们旨在测定糖尿病前期患者的致动脉粥样硬化指数（CRR、AC和AIP）及CIMT，然后评估它们之间的关系。本研究共纳入400名受试者，其中200名是糖尿病前期患者，200名是正常健康对照者。对每名受试者，根据常规血脂参数计算CRR、AC和AIP，并测量颈动脉内膜中层厚度。与对照组相比，糖尿病前期患者的致动脉粥样硬化指数，即CRR、AC和AIP显著升高（分别为5.87±0.87对4.23±0.50，P<0.001；4.87±0.87对3.23±0.50，P<0.001；0.29±0.07对0.09±0.09，P<0.001）。此外，观察到CIMT与AIP（r=0.529，P<0.01）、CRR（r=0.495，P<0.01）和AC（r=0.495，P<0.01）之间存在显著正相关。糖尿病前期患者存在致动脉粥样硬化指数和CIMT异常，这表明糖尿病前期发展为心血管疾病的倾向更大。因此，除常规血脂参数外，致动脉粥样硬化指数可用于更好地评估糖尿病前期患者的亚临床动脉粥样硬化。
