Kansal Subodh, Kamble T K
Resident.
Professor, Deptt. of Medicine, Chairman, Drug & Therapeutic Committee, Jawaharlal Nehru Medical College & Acharya Vinoba Bhave Rural Hospital, Datta Meghe Institute of Medical Sciences (University), Wardha, Maharashtra.
J Assoc Physicians India. 2016 Mar;64(3):18-21.
Dyslipidemia occurring in diabetic patients, play a critical role in acceleration of macrovascular atherosclerosis and contribute to the excess risk of CVD. Keeping in view the prevalence and increased risk of cardiovascular disease in diabetes, it is becoming necessary to diagnose prediabetic individuals and assess their lipid profile and prevent them from developing overt diabetes and hence preventing their further morbidity and mortality.
To study lipid profile in prediabetes.
This was a cross-sectional case control study, carried out between September 2012 - August 2014, which included 124 cases (prediabetic subjects) and101 healthy controls. Lipid profile of all identified prediabetic individuals and normal healthy controls was done and statistically analysed.
Total cholesterol, low density lipoprotein (LDL), triglyceride (TG), very low density lipoprotein, TG/HDL ratio and LDL/HDL ratio were significantly raised in prediabetic individuals as compared to normal healthy subjects, whereas high density lipoprotein (HDL) was significantly lower in prediabetic individuals as compared to normal healthy subjects.
Prediabetics had deranged lipid profile as compared to normal healthy subjects. These prediabetic individuals, because of their dyslipidemia, are at higher risk for developing cardiovascular disease. Lifestyle modification or pharmacotherapy in such individuals becomes a clinical consideration.
糖尿病患者中出现的血脂异常在加速大血管动脉粥样硬化过程中起关键作用，并导致心血管疾病风险增加。鉴于糖尿病中心血管疾病的患病率和风险增加，诊断糖尿病前期个体并评估其血脂谱，预防他们发展为显性糖尿病，从而预防其进一步的发病和死亡变得很有必要。
研究糖尿病前期的血脂谱。
这是一项横断面病例对照研究，于2012年9月至2014年8月进行，包括124例（糖尿病前期受试者）和101例健康对照。对所有确定的糖尿病前期个体和正常健康对照进行血脂谱检测并进行统计学分析。
与正常健康受试者相比，糖尿病前期个体的总胆固醇、低密度脂蛋白（LDL）、甘油三酯（TG）、极低密度脂蛋白、TG/HDL比值和LDL/HDL比值显著升高，而糖尿病前期个体的高密度脂蛋白（HDL）与正常健康受试者相比显著降低。
与正常健康受试者相比，糖尿病前期个体的血脂谱紊乱。这些糖尿病前期个体由于血脂异常，发生心血管疾病的风险更高。对此类个体进行生活方式改变或药物治疗成为临床考虑因素。
