鼻窦上皮-肌上皮癌：一个新发病部位的报告及文献综述
Sinonasal epithelial-myoepithelial carcinoma: Report of a novel subsite and review of the literature.
作者信息
Schuman Theodore A, Kimple Adam J, Edgerly Claire H, Ebert Charles S, Zanation Adam M, Thorp Brian D
机构信息
Department of Otolaryngology-Head and Neck Surgery, Virginia Commonwealth University School of Medicine, Richmond, Virginia.
Department of Otolaryngology-Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
出版信息
Allergy Rhinol (Providence). 2018 Apr 9;9:2152656718764229. doi: 10.1177/2152656718764229. eCollection 2018 Jan-Dec.
BACKGROUND
Epithelial-myoepithelial carcinoma (EMC) is a rare tumor of the major and minor salivary glands. Sinonasal EMC is extremely uncommon and hitherto not described within the frontal or ethmoid sinuses.
OBJECTIVE
To present a novel sinonasal subsite and review the literature regarding sinonasal EMC.
METHODS
A case of frontoethmoidal EMC was presented. A medical literature data base was queried from January 1, 1950, to August 8, 2017, for all reports of sinonasal EMC.
RESULTS
A 69-year-old man underwent combined open and endoscopic craniofacial resection of a right frontoethmoidal EMC, a previously undescribed primary location for this tumor. A comprehensive review of the literature revealed 13 additional cases of sinonasal EMC.
CONCLUSION
EMC is an uncommon neoplasm typically found in the major salivary glands; occurrence in the nose or paranasal sinuses is extremely rare. EMC often follows an indolent clinical course, although, in a minority of cases, particularly in large tumors with nuclear atypia, more aggressive behavior may be observed.
背景
上皮-肌上皮癌（EMC）是一种发生于大、小唾液腺的罕见肿瘤。鼻窦EMC极为罕见，迄今为止尚未见发生于额窦或筛窦的报道。
目的
介绍一种新的鼻窦发病部位，并对鼻窦EMC的相关文献进行综述。
方法
报告1例额筛窦EMC病例。检索1950年1月1日至2017年8月8日的医学文献数据库，查找所有鼻窦EMC的报道。
结果
1例69岁男性接受了开放性联合鼻内镜下颅面切除术，切除右侧额筛窦EMC，该肿瘤原发部位此前未见报道。全面的文献综述发现另外13例鼻窦EMC病例。
结论
EMC是一种罕见肿瘤，通常发生于大唾液腺；发生于鼻或鼻窦极为罕见。EMC通常临床过程较为惰性，不过，在少数病例中，尤其是肿瘤大且有核异型性时，可能观察到更具侵袭性的行为。
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