Affonso da Costa Ana Beatriz, Fornazari Bruna, da Silva Fernanda Perin Maia, Frandoloso Gibran A, Breda Giovanni L
1 Department of Internal Medicine, Hospital de Clínicas - UFPR, Curitiba, Brazil.
2 Division of Infectious Diseases, Hospital de Clínicas - UFPR, Curitiba, Brazil.
Int J STD AIDS. 2018 Nov;29(13):1348-1350. doi: 10.1177/0956462418785257. Epub 2018 Jul 6.
Despite the increasing incidence of syphilis and due to its wide variety of clinical manifestations, syphilis remains an under-diagnosed condition. We report an unusual case of secondary syphilis presenting with acute hepatitis and skin lesions, confirmed based on positive treponemal and non-treponemal assays. Despite adequate diagnosis and treatment, the patient developed fulminant hepatitis and brain death. This atypical presentation emphasizes the importance of high clinical suspicion in recognizing syphilis as an etiology for unexplained acute hepatitis, allowing early diagnosis and treatment and possibly avoiding severe complications such as fulminant hepatic failure.
尽管梅毒发病率不断上升，且临床表现多样，但梅毒仍是一种诊断不足的疾病。我们报告了一例罕见的二期梅毒病例，该病例表现为急性肝炎和皮肤损害，经梅毒螺旋体和非梅毒螺旋体检测呈阳性得以确诊。尽管诊断和治疗充分，但患者仍发展为暴发性肝炎并脑死亡。这种非典型表现强调了高度临床怀疑对于将梅毒识别为不明原因急性肝炎病因的重要性，以便早期诊断和治疗，并可能避免诸如暴发性肝衰竭等严重并发症。
