Department of Neurology (CA), Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; and Department of Neurology, Sinapse Neurologia e Reabilitação (CA), Rio de Janeiro, Brazil.
J Neuroophthalmol. 2018 Dec;38(4):511-513. doi: 10.1097/WNO.0000000000000682.
Seneca was a Roman philosopher, politician, and mentor to the young Nero. He later fell in disgrace and was sentenced to death by the Emperor. Seneca left many texts, one of the most influential being his Moral Letters to Lucilius (63 CE). In Letter 50, he describes the case of Harpaste, his wife's foolish slave who acutely became blind. She denied her illness and argued irrationally about room darkness, constantly asking attendants to change her quarters. Harpaste's case, consisting of acutely acquired blindness and anosognosia in the presence of relatively well-preserved cognition, fulfills the clinical criteria for the diagnosis of Anton syndrome, and probably constitutes its first description.
塞内加是罗马哲学家、政治家，也是年轻的尼禄的导师。后来，他失宠并被皇帝判处死刑。塞内加留下了许多著作，其中最有影响力的是他的《论道德的信札》（63 年）。在第 50 封信中，他描述了哈帕斯的案例，他是他妻子愚蠢的奴隶，突然失明了。她否认自己有病，并对房间的黑暗不合理地争论，不断要求仆人更换她的住处。哈帕斯的案例包括急性失明和认知相对完好的情况下的否认，符合 Anton 综合征的临床诊断标准，可能是其首次描述。
