Zhao Ling-Jun, Wang Ping, He Ying
Departments of Gynecology Departments of Pathology, Sichuan University West China Second University Hospital, Key Laboratory of Birth Defects and Related Disease of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.
Medicine (Baltimore). 2018 Jul;97(27):e11330. doi: 10.1097/MD.0000000000011330.
Ovarian malignancy is associated with one of the highest rates of death among gynecological reproductive system malignancies. While progress has been made in surgical and postoperative adjuvant treatment approaches, the early atypical clinical manifestations, quick progression, and lack of the effective early screening means imply that the prognosis remains poor. Bilateral ovarian cancers are common, but different types of primary bilateral ovarian carcinomas are extremely rare.
According to clinical pathologic, immunohistochemistry, and medical imaging data, a 51-year-old Chinese woman with abdominal pain was diagnosed as having right ovarian well-differentiated endometrioid adenocarcinoma with mucinous adenocarcinoma and left ovarian clear cell adenocarcinoma.
Immunohistochemistry confirmed the diagnosis of primary bilateral ovarian cancers.
She received multimodal treatment including surgery and chemotherapy.
The patient's recovery was uneventful, and she responded well to the chemotherapy.
We speculate that the different types of primary bilateral ovarian carcinomas presented in this case may be due to different malignant transformations of the endometriotic lesions. Therefore, clinicians should pay special attention to the possible malignant transformation of endometriosis.
卵巢恶性肿瘤是妇科生殖系统恶性肿瘤中死亡率最高的疾病之一。虽然在手术及术后辅助治疗方法方面已取得进展，但早期非典型临床表现、快速进展以及缺乏有效的早期筛查手段意味着预后仍然很差。双侧卵巢癌很常见，但不同类型的原发性双侧卵巢癌极为罕见。
根据临床病理、免疫组化和医学影像数据，一名51岁腹痛的中国女性被诊断为右卵巢高分化子宫内膜样腺癌伴黏液腺癌，左卵巢透明细胞腺癌。
免疫组化确诊为原发性双侧卵巢癌。
她接受了包括手术和化疗在内的多模式治疗。
患者恢复顺利，对化疗反应良好。
我们推测该病例中出现的不同类型的原发性双侧卵巢癌可能是由于子宫内膜异位病变的不同恶性转化所致。因此，临床医生应特别注意子宫内膜异位症可能发生的恶性转化。
