Hasegawa Keita, Yoshihama Tomoko, Takahashi Mio, Nakazato Norihiko, Suga Yukako, Iguchi Yoko, Ueyama Yoshito, Itoh Masaaki, Sakurai Nobuyuki
Department of Obstetrics and Gynecology, Inagi Municipal Hospital, 1171, Omaru, Inagi, Tokyo, 206-0801 Japan.
Department of Pathology, Inagi Municipal Hospital, 1171, Omaru, Inagi, Tokyo, 206-0801 Japan.
Int Cancer Conf J. 2024 Jun 4;13(4):360-366. doi: 10.1007/s13691-024-00686-2. eCollection 2024 Oct.
Although ovarian cancer is generally unilateral, a few cases of bilateral ovarian cancer have been reported, most of which originate from metastases of unilateral ovarian cancer. However, synchronous primary bilateral ovarian cancer (SBOC), comprising two different histological types of ovarian cancer, is extremely rare, with limited reports on its clinical course and prognosis. Herein, we report the case of a 56-year-old postmenopausal Japanese woman with stage IVB SBOC with combined left ovarian clear cell and right ovarian mucinous carcinomas. The patient underwent surgery and received postoperative taxane/platinum-based chemotherapy, which temporarily reduced the tumor size. However, an increase in tumor size and brain metastases were subsequently identified. Treatment was accordingly discontinued, and the patient died of the disease 12 months after diagnosis. In this case report, we detail the clinical course of a case of SBOC. To the best of our knowledge, this is the first report of SBOC with combined histological types of clear cell and mucinous carcinomas, and it is also the first report of SBOC with the eventual discovery of brain metastases.
尽管卵巢癌通常为单侧发生，但已有少数双侧卵巢癌的病例报道，其中大多数起源于单侧卵巢癌的转移。然而，同步原发性双侧卵巢癌（SBOC），即包含两种不同组织学类型的卵巢癌，极为罕见，关于其临床病程和预后的报道有限。在此，我们报告一例56岁绝经后日本女性，患有IVB期SBOC，合并左卵巢透明细胞癌和右卵巢黏液性癌。患者接受了手术，并接受了术后紫杉烷/铂类化疗，肿瘤大小暂时缩小。然而，随后发现肿瘤大小增加并出现脑转移。治疗因此中断，患者在诊断后12个月死于该疾病。在本病例报告中，我们详细描述了一例SBOC的临床病程。据我们所知，这是首例合并透明细胞和黏液性癌组织学类型的SBOC报告，也是首例最终发现脑转移的SBOC报告。
