Research Department, Rinaldi Fontani Foundation, Florence, Italy.
Department of Regenerative and Anti-Aging Medicine, Rinaldi Fontani Institute, Florence, Italy.
PLoS One. 2018 Jul 6;13(7):e0200128. doi: 10.1371/journal.pone.0200128. eCollection 2018.
Alterations of the gravitational environment are likely to modify cell behavior. Several studies have proven that T cells are sensitive to gravity alterations and that microgravity conditions may induce immunosuppression and weakened T cell immune response in humans during spaceflights. The aim of this work was to elucidate if a specific treatment of Radio Electric Asymmetric Conveyer (REAC) technology could restore, after mitogenic activation (Con A), a correct expression of cytokine IL2 gene and its receptor IL2R alpha, which are inhibited in T cells under microgravity conditions, as demonstrated in several studies. The results of this study, conducted in microgravity simulated with Random Positioning Machine (RPM), confirm the T cell activation recovery and offer the evidence that REAC technology could contribute to the understanding of T cell growth responsiveness in space, reducing the impact of weightlessness on the immune system experienced by humans in long duration space missions.
重力环境的改变可能会改变细胞的行为。有几项研究已经证明，T 细胞对重力变化敏感，微重力条件可能会在人类的太空飞行中引起免疫抑制和减弱 T 细胞免疫反应。这项工作的目的是阐明放射性电动不对称输送（REAC）技术的一种特殊处理是否可以在有丝分裂原激活（Con A）后恢复细胞因子 IL2 基因及其受体 IL2R alpha 的正确表达，正如在几项研究中证明的那样，在微重力条件下，T 细胞中的这些基因和受体受到抑制。这项在随机定位机（RPM）模拟微重力下进行的研究的结果证实了 T 细胞的激活恢复，并提供了证据，表明 REAC 技术可能有助于理解太空飞行中 T 细胞生长的反应性，从而减轻人类在长期太空任务中经历的微重力对免疫系统的影响。
