Department of Psychiatry, Nagoya University, Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8560, Japan.
Department of Psychiatry, Nagoya University, Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8560, Japan; Institute for Advanced Research, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8601, Japan.
Psychiatry Res Neuroimaging. 2018 Aug 30;278:35-41. doi: 10.1016/j.pscychresns.2018.06.007. Epub 2018 Jun 21.
Resting-state (rs) functional magnetic resonance imaging (fMRI) studies have revealed dysfunctional thalamocortical functional connectivity (FC) in schizophrenia. However, the relationship between thalamocortical FC and cognitive impairment has not been thoroughly investigated. We hypothesized that aberrant thalamocortical FC is related to attention deficits in schizophrenia. Thirty-eight patients with schizophrenia and 38 matched healthy controls underwent rs-fMRI and task fMRI while performing a Flanker task. We observed decreased left thalamic activation in patients with schizophrenia using task fMRI to determine the thalamic seed. A seed-based analysis using this seed was performed in the whole brain to assess differences in thalamocortical FC between the groups. Significantly worse performance was observed in the patient group. The rs-fMRI analysis revealed significantly increased FC between the left thalamus seed and the occipital cortices/postcentral gyri in patients when compared to controls. In the patient group, significant positive correlations were observed between the degree of FC from the left thalamus to the bilateral occipital gyri, which correspond to the visual cortex, and the Flanker effect. No significant correlation was detected in the control group. These results indicate that aberrant FC between the left thalamus and the visual cortex is related to attention deficits in schizophrenia.
静息态功能磁共振成像 (rs-fMRI) 研究揭示了精神分裂症患者丘脑-皮质功能连接 (FC) 异常。然而，丘脑-皮质 FC 与认知障碍之间的关系尚未得到深入研究。我们假设异常的丘脑-皮质 FC 与精神分裂症患者的注意力缺陷有关。38 名精神分裂症患者和 38 名匹配的健康对照者接受了 rs-fMRI 和任务 fMRI 检查，同时进行 Flanker 任务。我们使用任务 fMRI 观察到精神分裂症患者左丘脑活动减少，以确定丘脑种子。使用该种子在全脑进行种子基础分析，以评估组间丘脑-皮质 FC 的差异。患者组的表现明显较差。rs-fMRI 分析显示，与对照组相比，患者组左侧丘脑种子与枕叶皮质/中央后回之间的 FC 显著增加。在患者组中，左侧丘脑到双侧枕叶回（对应视觉皮层）的 FC 程度与 Flanker 效应之间存在显著正相关，而对照组中未检测到显著相关性。这些结果表明，左侧丘脑与视觉皮层之间异常的 FC 与精神分裂症患者的注意力缺陷有关。
