纳米金刚石的慢性毒性会干扰东亚飞蝗的生长发育和繁殖。

Chronic toxicity of nanodiamonds can disturb development and reproduction of Acheta domesticus L.

机构信息

Department of Animal Physiology and Ecotoxicology, University of Silesia in Katowice, Bankowa 9, PL 40-007 Katowice, Poland.

出版信息

Environ Res. 2018 Oct;166:602-609. doi: 10.1016/j.envres.2018.05.027. Epub 2018 Jul 3.

DOI:10.1016/j.envres.2018.05.027

PMID:29982148

Abstract

UNLABELLED

The use of nanodiamonds in numerous materials designed for industry and medicine is growing rapidly. Consequently health and environmental risks associated with the exposure of humans and other biota to nanodiamonds-based materials are of the utmost importance. Scarcity of toxicological data for these particles led us to examine the potentially deleterious effects of nanodiamonds in model insect species, Acheta domesticus (Orthoptera) chronically exposed to ND in its diet. Organism-level end-point indices (lifespan, body weight, consumption, caloric value of faeces, reproduction) revealed adverse changes in the treated crickets in comparison with the control. Preliminary studies of oxidative stress level in the offspring of ND-treated crickets suggest toxicity of these particles limited to the exposed individuals. EPR analysis showing increase of radical signal in the faeces of ND-fed crickets led us to propose novel mechanism of nanodiamonds toxicity that is discussed in the light of literature data.

CAPSULE

Development and reproduction of Acheta domesticus can be disturbed by the chronic exposure to nanodiamonds.

摘要

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纳米金刚石在众多工业和医药设计材料中的应用正在迅速增长。因此，与人类和其他生物群暴露于基于纳米金刚石的材料相关的健康和环境风险至关重要。由于这些颗粒的毒理学数据稀缺，我们研究了纳米金刚石在模式昆虫物种（直翅目）中的潜在有害影响，这些昆虫在其饮食中长期暴露于 ND。与对照组相比，生物体水平的终点指标（寿命、体重、消耗、粪便热值、繁殖）显示出处理蟋蟀的不良变化。对 ND 处理蟋蟀后代的氧化应激水平的初步研究表明，这些颗粒的毒性仅限于暴露个体。EPR 分析显示，在喂食 ND 的蟋蟀的粪便中自由基信号增加，这使我们提出了纳米金刚石毒性的新机制，该机制根据文献数据进行了讨论。