Jović Danica, Jaćević Vesna, Kuča Kamil, Borišev Ivana, Mrdjanovic Jasminka, Petrovic Danijela, Seke Mariana, Djordjevic Aleksandar
Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovića 3, 21000 Novi Sad, Serbia.
Department for Experimental Toxicology and Pharmacology, National Poison Control Centre, Military Medical Academy, Crnotravska 17, 11040 Belgrade, Serbia.
Nanomaterials (Basel). 2020 Jul 31;10(8):1508. doi: 10.3390/nano10081508.
Being a member of the nanofamily, carbon nanomaterials exhibit specific properties that mostly arise from their small size. They have proved to be very promising for application in the technical and biomedical field. A wide spectrum of use implies the inevitable presence of carbon nanomaterials in the environment, thus potentially endangering their whole nature. Although scientists worldwide have conducted research investigating the impact of these materials, it is evident that there are still significant gaps concerning the knowledge of their mechanisms, as well as the prolonged and chronic exposure and effects. This manuscript summarizes the most prominent representatives of carbon nanomaterial groups, giving a brief review of their general physico-chemical properties, the most common use, and toxicity profiles. Toxicity was presented through genotoxicity and the activation of the cell signaling pathways, both including and models, mechanisms, and the consequential outcomes. Moreover, the acute toxicity of fullerenol, as one of the most commonly investigated members, was briefly presented in the final part of this review. Thinking small can greatly help us improve our lives, but also obliges us to deeply and comprehensively investigate all the possible consequences that could arise from our pure-hearted scientific ambitions and work.
作为纳米家族的一员，碳纳米材料展现出一些特定的性质，这些性质大多源于其微小的尺寸。事实证明，它们在技术和生物医学领域的应用前景十分广阔。广泛的用途意味着碳纳米材料不可避免地会存在于环境中，从而可能危及整个生态环境。尽管世界各地的科学家都在进行研究，探究这些材料的影响，但显然在它们的作用机制、长期和慢性暴露及影响方面，仍存在重大知识空白。本手稿总结了碳纳米材料类别的最突出代表，简要回顾了它们的一般物理化学性质、最常见用途和毒性概况。通过遗传毒性和细胞信号通路的激活来阐述毒性，包括相关模型、机制和相应结果。此外，作为最常被研究的成员之一，富勒醇的急性毒性在本综述的最后部分进行了简要介绍。从小处着眼能极大地帮助我们改善生活，但也迫使我们深入全面地研究，我们单纯的科学抱负和工作可能产生的所有潜在后果。
