Rashidbeygi Elaheh, Rahimi Mohammad Hossein, Mollahosseini Mehdi, Yekaninejad Mir Saeed, Imani Hossein, Maghbooli Zhila, Mirzaei Khadijeh
Department of Community Nutrition, School of Nutrition and Food Science, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Diabetes Metab Syndr. 2018 Nov;12(6):985-990. doi: 10.1016/j.dsx.2018.06.010. Epub 2018 Jun 28.
Recent studies have shown that Vitamin D deficiency is very common globally. Vitamin D deficiency is associated with lipid metabolism. A relationship between vitamin D levels and waist circumference (WC) has been observed. The purpose of this study is to evaluate the relationship between vitamin D status and metabolic dyslipidemia and the hypertriglyceridemic waist phenotype.
This cross-sectional study was conducted on 265 healthy Tehran adults. Hypertriglyceridemic waist phenotype (HTGWP) was described as serum triacylglycerol concentrations >150 mg/dL and concurrent WC > 88 cm (women) and >102 cm (men). Dyslipidemia was defined as: 1) TG level of >150 mg/dL 2) HDL > 40 mg/dL for men or >50 mg/dL for women, as has been previously described.
Current study's results demonstrated that HTGWP was significantly associated with weight, age, WC, hip, fat percent, TG, lipid profile, ALT and BMI. We found 77% reduction in the chances of developing metabolic dyslipidemia in suficient satus of vitamin D in compare to deficiency, although the significancy was mariginal, OR: 0.33, 95% CI of 0.09 to 1.21, P = 0.09. However, our results revealed that vitamin D deficiency, compared with normal status, can increase the risk of phenotype 1 (high TG/high WC); OR: 3.86 and 95% CI from 0.86 to 0.99, p for trend = 0.05.
Significant associations were found between vitamin D status and HTGWP. In addition, there was a relationship between vitamin D and lipid profiles. There is a direct correlation between TG and waist circumference in insulin resistance in healthy Tehran adults.
近期研究表明，维生素D缺乏在全球范围内非常普遍。维生素D缺乏与脂质代谢有关。已观察到维生素D水平与腰围（WC）之间存在关联。本研究的目的是评估维生素D状态与代谢性血脂异常及高甘油三酯腰围表型之间的关系。
本横断面研究对265名健康的德黑兰成年人进行。高甘油三酯腰围表型（HTGWP）定义为血清三酰甘油浓度>150mg/dL，同时女性腰围>88cm，男性腰围>102cm。血脂异常的定义为：1）甘油三酯（TG）水平>150mg/dL；2）高密度脂蛋白（HDL）男性>40mg/dL，女性>50mg/dL，如先前所述。
当前研究结果表明，HTGWP与体重、年龄、腰围、臀围、脂肪百分比、TG、血脂谱、谷丙转氨酶（ALT）和体重指数（BMI）显著相关。我们发现，与维生素D缺乏相比，维生素D充足状态下发生代谢性血脂异常的几率降低了77%，尽管差异不显著，比值比（OR）：0.33，95%置信区间（CI）为0.09至1.21，P = 0.09。然而，我们的结果显示，与正常状态相比，维生素D缺乏会增加表型1（高TG/高腰围）的风险；OR：3.86，95%CI为0.86至0.99，趋势p = 0.05。
发现维生素D状态与HTGWP之间存在显著关联。此外维生素D与血脂谱之间存在关系。在健康的德黑兰成年人中，胰岛素抵抗时TG与腰围之间存在直接相关性。
