Khanal Laxmi Kant, Adhikari Ram Prasad, Guragain Ankita
Department of Microbiology, Nepal Medical College Teaching Hospital, Jorpati, Kathmandu, Nepal.
J Nepal Health Res Counc. 2018 Jul 3;16(2):172-174.
Methicillin resistant Staphylococcus aureus is a global health challenge nowadays creating problem in antibiotic therapy. This study was aimed to generate resistance pattern of Methicillin resistant Staphylococcus aureus to various antibiotics in order to formulate antibiotic policy for control of Methicillin resistant Staphylococcus aureus in Nepal.
This was a cross-sectional study conducted at the department of Clinical Microbiology, Nepal Medical College Teaching Hospital, from April 2015 to March 2016. A total of 142 S. aureus isolated from various clinical specimens. were screened for Methicillin resistant Staphylococcus aureus by cefoxitin disc method according to Clinical and Laboratory Standards Institute guidelines.
Out of 142 S. aureus isolates, 30 (21.1%) were detected as Methicillin resistant Staphylococcus aureus by cefoxitin disc method. Most of the Methicillin resistant Staphylococcus aureus (25/30) were isolated from pus which were collected from OPD patients. Antibiotic sensitivity pattern showed all Methicillin resistant Staphylococcus aureus isolates were sensitive to vancomycin.
Prevalence of Methicillin resistant Staphylococcus aureus was found to be 21.1%, and all Methicillin resistant Staphylococcus aureus appear 100% sensitive to vancomycin.
耐甲氧西林金黄色葡萄球菌是当今全球健康面临的挑战，给抗生素治疗带来难题。本研究旨在得出耐甲氧西林金黄色葡萄球菌对各种抗生素的耐药模式，以便制定尼泊尔控制耐甲氧西林金黄色葡萄球菌的抗生素政策。
这是一项于2015年4月至2016年3月在尼泊尔医学院教学医院临床微生物科进行的横断面研究。从各种临床标本中分离出142株金黄色葡萄球菌。根据临床和实验室标准协会指南，采用头孢西丁纸片法筛选耐甲氧西林金黄色葡萄球菌。
在142株金黄色葡萄球菌分离株中，通过头孢西丁纸片法检测出30株（21.1%）为耐甲氧西林金黄色葡萄球菌。大多数耐甲氧西林金黄色葡萄球菌（25/30）分离自从门诊患者收集的脓液。抗生素敏感性模式显示，所有耐甲氧西林金黄色葡萄球菌分离株对万古霉素敏感。
耐甲氧西林金黄色葡萄球菌的患病率为21.1%，且所有耐甲氧西林金黄色葡萄球菌对万古霉素的敏感性均为100%。
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