Chen Yu, Tang Weifeng, Liu Chao, Lin Jing, Wang Yafeng, Zhang Sheng, Chen Gang, Zheng Xiongwei
Department of Medical Oncology, Fujian Cancer Hospital and Fujian Medical University Cancer Hospital, Fuzhou, Fujian Province, China.
Cancer Bio-Immunotherapy Center, Fujian Cancer Hospital and Fujian Medical University Cancer Hospital, Fuzhou, Fujian Province, China.
Cancer Manag Res. 2018 Jun 25;10:1657-1664. doi: 10.2147/CMAR.S165921. eCollection 2018.
The miRNA-146a rs2910164 C>G polymorphism may contribute to the development of cancer. However, the association between this polymorphism and the risk of esophagogastric junction adenocarcinoma (EGJA) remains unclear. In the present study, we carried out a case-control study to explore the potential relationship between miRNA-146a rs2910164 C>G polymorphism and EGJA risk.
In total, 1,063 EGJA patients and 1,677 cancer-free controls were enrolled. The SNPscan genotyping assay, a patented technology, was used to test the genotyping of miRNA-146a rs2910164 C>G polymorphism.
We found that miRNA-146a rs2910164 C>G polymorphism was associated with a risk of developing EGJA (additive model: adjusted odds ratio (OR), 1.27; 95% CI, 1.07-1.51; =0.006; homozygote model: adjusted OR, 1.31; 95% CI, 1.03-1.65; =0.027 and dominant model: adjusted OR, 1.36; 95% CI, 1.15-1.60; <0.001). After adjustment for the Bonferroni correction, these associations were also found in additive and dominant genetic models. In the subgroup analyses, after adjustment by sex, age, alcohol consumption, and smoking status, results of multiple logistic regression analysis indicated that miRNA-146a rs2910164 C>G polymorphism increased the risk of EGJA in males, females, <64 years old, ≥64 years old, never smoking, and never drinking subgroups.
The current study highlights that the miRNA-146a rs2910164 C>G polymorphism increased the risk of EGJA in eastern Chinese Han population.
miRNA - 146a rs2910164 C>G多态性可能与癌症的发生有关。然而，这种多态性与食管胃交界腺癌（EGJA）风险之间的关联仍不清楚。在本研究中，我们进行了一项病例对照研究，以探讨miRNA - 146a rs2910164 C>G多态性与EGJA风险之间的潜在关系。
总共纳入了1063例EGJA患者和1677例无癌对照。采用专利技术SNPscan基因分型检测法检测miRNA - 146a rs2910164 C>G多态性的基因分型。
我们发现miRNA - 146a rs2910164 C>G多态性与发生EGJA的风险相关（相加模型：调整后的比值比（OR）为1.27；95%置信区间为1.07 - 1.51；P = 0.006；纯合子模型：调整后的OR为1.31；95%置信区间为1.03 - 1.65；P = 0.027；显性模型：调整后的OR为1.36；95%置信区间为1.15 - 1.60；P < 0.001）。经过Bonferroni校正后，在相加和显性遗传模型中也发现了这些关联。在亚组分析中，经性别、年龄、饮酒和吸烟状况调整后，多因素logistic回归分析结果表明，miRNA - 146a rs2910164 C>G多态性增加了男性、女性、<64岁、≥64岁、从不吸烟和从不饮酒亚组中EGJA的风险。
当前研究强调，miRNA - 146a rs2910164 C>G多态性增加了中国东部汉族人群患EGJA的风险。
