非中性粒细胞减少患者致死性肺部感染的微生物学和免疫学特征
Microbiological and immunological characteristics of a lethal pulmonary infection in a non-neutropenic patient.
作者信息
Workum Jessica D, de Jong Suzanne W, Gresnigt Mark S, Becker Katharina L, Pickkers Peter, van de Veerdonk Frank L, Heijdra Yvonne F, Kolwijck Eva
机构信息
Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
出版信息
Med Mycol Case Rep. 2018 Mar 7;21:4-7. doi: 10.1016/j.mmcr.2018.03.002. eCollection 2018 Sep.
Invasive pulmonary aspergillosis is increasingly described in non-neutropenic patients, such as patients with COPD receiving corticosteroids and the critically ill. Here, we present a case of a lethal pulmonary infection in a COPD patient. Immunological tests showed an impaired innate and adaptive immune response to . A history of COPD, unresponsiveness to antibiotics and especially a suggestive CT-scan should trigger the clinician to consider diseases caused by
侵袭性肺曲霉病在非中性粒细胞减少患者中越来越多地被描述，如接受皮质类固醇治疗的慢性阻塞性肺疾病（COPD）患者和危重症患者。在此，我们报告一例COPD患者发生的致命性肺部感染病例。免疫检测显示对……的先天性和适应性免疫反应受损。COPD病史、对抗生素无反应，尤其是具有提示性的CT扫描结果，应促使临床医生考虑由……引起的疾病
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