印度尼西亚劳动年龄人群中糖尿病患者肾功能不全的患病率及相关危险因素
Prevalence of kidney dysfunction in diabetes mellitus and associated risk factors among productive age Indonesian.
作者信息
Mihardja Laurentia, Delima Delima, Massie Roy G A, Karyana Muhammad, Nugroho Pringgodigdo, Yunir Em
机构信息
1National Institute of Health Research and Development, Ministry of Health, Percetakan Negara no 29, Jakarta, Indonesia.
2Department of Internal Medicine, Medical Faculty, University of Indonesia, Jakarta, Indonesia.
出版信息
J Diabetes Metab Disord. 2018 Mar 27;17(1):53-61. doi: 10.1007/s40200-018-0338-6. eCollection 2018 Jun.
BACKGROUND
The prevalence of diabetes mellitus is increasing in Indonesia due to population growth, urbanization, and lifestyle. Diabetes mellitus (DM) is the leading cause of chronic kidney disease that escalates mortality rate, but not all DM develop into chronic kidney disease.
AIMS
To estimate the prevalence of kidney dysfunction (KD) in DM and the associated dominant risk factors among productive age Indonesian based on the National Health Survey () 2013.
METHODS
The statistical data consisted of 15,791 females and 10,349 males, aged 20 to 54, who lived in rural and urban areas. The data was obtained from National Institute of Health Research and Development (NIHRD), Ministry of Health. Data were collected from 33 provinces using cross sectional method. The variables data analyzed were sociodemographic, lifestyle, anthropometric, blood pressure, blood lipid, blood glucose, and creatinine. Kidney dysfunction was defined according to Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. Multivariable logistic regression was used to analyze the dominant associated risk factors.
RESULTS
The prevalence of KD in DM was 4% (CI 95% 3.1-5.1) and only 0.6% had been diagnosed. Many associated risk factors could affect DM leading to KD such as age, sex, rural, economic status, sugary food/drinks, salty food, coffee, hypertension, hypercholesterolemia, low HDL, high LDL, and hypertriglyceridemia. The dominant associated risk factors were age, sex, economic status, sugary food/drinks, and low HDL.
CONCLUSION
The prevalence of KD in DM among productive age Indonesian was 4% and only 0.6% had been diagnosed. Early detection of identification of KD in DM is needed in order to slow progression and complications. The dominant associated risk factors of KD in DM were age, sex, economic status, sugary food/drinks, and low HDL. Controlling of risk factors in DM should be done in order to prevent diabetic kidney disease.
背景
由于人口增长、城市化和生活方式的改变，印度尼西亚糖尿病的患病率正在上升。糖尿病（DM）是慢性肾脏病的主要病因，会使死亡率升高，但并非所有糖尿病患者都会发展为慢性肾脏病。
目的
根据2013年全国健康调查，估计印度尼西亚适龄人群中糖尿病患者的肾功能不全（KD）患病率及相关主要危险因素。
方法
统计数据包括15791名女性和10349名男性，年龄在20至54岁之间，居住在农村和城市地区。数据来自卫生部国家卫生研究与发展研究所（NIHRD）。采用横断面方法从33个省份收集数据。分析的变量数据包括社会人口统计学、生活方式、人体测量学、血压、血脂、血糖和肌酐。肾功能不全根据慢性肾脏病流行病学协作组（CKD-EPI）方程定义。采用多变量逻辑回归分析主要相关危险因素。
结果
糖尿病患者中肾功能不全的患病率为4%（95%置信区间3.1-5.1），仅有0.6%的患者被诊断出。许多相关危险因素可影响糖尿病导致肾功能不全，如年龄、性别、农村地区、经济状况、含糖食物/饮料、咸食、咖啡、高血压、高胆固醇血症、低高密度脂蛋白、高低密度脂蛋白和高甘油三酯血症。主要相关危险因素为年龄、性别、经济状况、含糖食物/饮料和低高密度脂蛋白。
结论
印度尼西亚适龄人群中糖尿病患者肾功能不全的患病率为4%，仅有0.6%的患者被诊断出。需要对糖尿病患者进行肾功能不全的早期检测，以减缓疾病进展和并发症。糖尿病患者肾功能不全的主要相关危险因素为年龄、性别、经济状况、含糖食物/饮料和低高密度脂蛋白。应控制糖尿病患者的危险因素以预防糖尿病肾病。
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