Lin Mengyue, Heizhati Mulalibieke, Wang Lin, Gan Lin, Li Mei, Yang Wenbo, Yao Ling, Wang Zhongrong, Yang Zhikang, Abudoyreyimu Reyila, Wu Zihao, Li Nanfang
Xinjiang Medical University, Urumqi, People's Republic of China.
Hypertension Center of the People's Hospital of Xinjiang Uygur Autonomous Region; Xinjiang Hypertension Institute; National Health Committee Key Laboratory of Hypertension Clinical Research, Urumqi, Xinjiang, People's Republic of China.
Int J Gen Med. 2021 Nov 2;14:7567-7578. doi: 10.2147/IJGM.S329604. eCollection 2021.
The burden of kidney dysfunction (KD) is rapidly increasing in developing countries due to an ongoing epidemic of hypertension and diabetes. We aimed to evaluate the prevalence and associated factors of KD among population with hypertension and/or diabetes from primary care setting.
This study was part of a cross-sectional study conducted in Northwest China, which aimed to investigate the epidemiological status of hypertension and other chronic noninfectious diseases. Subjects aged ≥18 years old with hypertension and/or diabetes were included in this study. KD was defined as estimated glomerular filtration rate (eGFR) less than 60 mL/min/1.73m. Least absolute shrinkage and selection operator and multivariable logistic regression were used to identify factors associated with KD. Sensitivity analysis was performed by comparing the results of different estimated equations for GFR.
A total of 8899 participants with hypertension and/or diabetes were included. Prevalence of KD was 8.69% (n=144) among patients with both hypertension and DM, 3.36% (n=198) among patients with only hypertension, and 5.22% (n=70) among patients with only diabetes. Women showed higher prevalent KD than men. Modifiable factors independently associated with KD among patients with hypertension and/or diabetes included physical activity, duration of hypertension or DM, anemia, fasting plasma glucose and triglyceride. Results of different estimated equations showed similar trends of difference in the prevalence of KD among groups.
KD is common in patients with hypertension and/or DM in Northwest China. More attention should be paid to high-risk patients, especially to those with co-existence of hypertension and DM. Control of blood glucose and triglyceride may further improve KD management in this patient population.
由于高血压和糖尿病的持续流行，发展中国家肾功能不全（KD）的负担正在迅速增加。我们旨在评估基层医疗环境中高血压和/或糖尿病患者中KD的患病率及相关因素。
本研究是在中国西北部进行的一项横断面研究的一部分，该研究旨在调查高血压和其他慢性非传染性疾病的流行病学状况。本研究纳入了年龄≥18岁的高血压和/或糖尿病患者。KD定义为估计肾小球滤过率（eGFR）低于60 mL/min/1.73m²。使用最小绝对收缩和选择算子以及多变量逻辑回归来确定与KD相关的因素。通过比较不同GFR估计方程的结果进行敏感性分析。
共纳入8899名高血压和/或糖尿病参与者。高血压合并糖尿病患者中KD的患病率为8.69%（n = 144），仅患有高血压的患者中为3.36%（n = 198），仅患有糖尿病的患者中为5.22%（n = 70）。女性的KD患病率高于男性。高血压和/或糖尿病患者中与KD独立相关的可改变因素包括身体活动、高血压或糖尿病病程、贫血、空腹血糖和甘油三酯。不同估计方程的结果显示各组间KD患病率差异趋势相似。
在中国西北部，KD在高血压和/或糖尿病患者中很常见。应更加关注高危患者，尤其是那些同时患有高血压和糖尿病的患者。控制血糖和甘油三酯可能会进一步改善该患者群体的KD管理。
