Department of Gynecological Endocrinology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Poland.
Chair of Physiotherapy, School of Health Science in Katowice, Medical University of Silesia, Poland.
Ginekol Pol. 2020;91(5):251-255. doi: 10.5603/GP.2020.0056.
The study aimed to assess the associations between circulating vaspin levels and nutritional status (assessed on tha basis of BMI) as well as insulin resistance in PCOS.
Eighty-seven PCOS women, 48 obese and 39 normal weight, were enrolled in the cross-sectional study. Seventy-two Non-PCOS women, 41 obese and 31 normal weight, constituted a control group. Body mass, height and waist circumference as well as body composition by bioimpedance were measured. In the morning (16h after the last meal) we determined: serum glucose, insulin, androgens, gonadotropin (LH, FSH) and sex hormone-binding globulin (SHBG) as well as plasma vaspin levels. Standard HOMA-IR formula was used to assess insulin resistance (IR).
Plasma vaspin levels were significantly lower in PCOS, both normal weight and obese, than in Non-PCOS groups. Vaspin levels were similar in normal weight and obese PCOS subgroups. There was no association between plasma vaspin levels and anthropometric parameters in PCOS group. While in Non-PCOS group a negative correlation between plasma vaspin levels and body mass (r = -0.26; p < 0.05) was found. We did not observe correlations between plasma vaspin levels and serum glucose and insulin concentrations as well as HOMA-IR values, however, in multivariable, stepwise backward regression waist circumference and HOMA-IR values explained 18.0% of plasma vaspin levels variability in the study subjects.
PCOS occurrence is associated with decreased vaspin levels. The influence of nutritional status on vaspin level observed in Non-PCOS is abolished in PCOS women, possibly by more severe insulin resistance.
本研究旨在评估循环中 vaspin 水平与多囊卵巢综合征（PCOS）患者的营养状况（基于 BMI 评估）和胰岛素抵抗之间的相关性。
本横断面研究纳入了 87 名 PCOS 女性，其中 48 名肥胖，39 名体重正常；还纳入了 72 名非 PCOS 女性，其中 41 名肥胖，31 名体重正常。测量了体重、身高和腰围以及生物阻抗法测定的身体成分。次日上午（最后一餐 16 小时后），我们测定了血清葡萄糖、胰岛素、雄激素、促性腺激素（LH、FSH）和性激素结合球蛋白（SHBG）以及血浆 vaspin 水平。采用标准 HOMA-IR 公式评估胰岛素抵抗（IR）。
与非 PCOS 组相比，PCOS 患者，无论体重正常还是肥胖，血浆 vaspin 水平均显著降低。正常体重和肥胖的 PCOS 亚组之间 vaspin 水平相似。在 PCOS 组中，血浆 vaspin 水平与人体测量参数之间无相关性。而非 PCOS 组中，血浆 vaspin 水平与体重呈负相关（r = -0.26；p < 0.05）。我们未观察到血浆 vaspin 水平与血清葡萄糖和胰岛素浓度以及 HOMA-IR 值之间存在相关性，然而，多元逐步向后回归显示，腰围和 HOMA-IR 值解释了研究对象中血浆 vaspin 水平变化的 18.0%。
PCOS 的发生与 vaspin 水平降低有关。在 PCOS 女性中，营养状况对 vaspin 水平的影响被消除，这可能是由于胰岛素抵抗更为严重。
