Department of Nutrition and Dietetics, Artvin Coruh University Faculty of Healthy Sciences, Artvin, Turkey.
Department of Urology, Hopa State Hospital, Artvin, Turkey.
Investig Clin Urol. 2018 Jul;59(4):252-256. doi: 10.4111/icu.2018.59.4.252. Epub 2018 Jun 14.
In this study, we aimed to explain the role of oxidative stress in women with overactive bladder (OAB) by investigating the levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, and malondialdehyde (MDA), an indicator of lipid peroxidation.
A total of 90 women were included in the study: 45 female patients diagnosed with OAB at Hopa State Hospital Urology Polyclinic and 45 healthy women without any metabolic or neurologic disease. Levels of MDA and 8-OHdG were measured in 24-hour urine samples for all subjects.
Urinary levels of MDA and 8-OHdG were significantly higher in the OAB group than in the control group (p<0.001). A significant positive correlation (p<0.001) was found between the measurements of 8-OHdG and MDA.
Oxidative stress may be important in the pathophysiology of OAB, because levels of 8-OHdG and MDA are increased. Increased levels of 8-OHdG may be due to damaged nuclear and mitochondrial DNA as a result of oxidative attacks caused by free radicals. Nevertheless, further randomized and prospective studies with larger patient populations are needed.
本研究旨在通过检测氧化应激标志物 8-羟基-2'-脱氧鸟苷（8-OHdG）和脂质过氧化标志物丙二醛（MDA）的水平，探讨氧化应激在女性膀胱过度活动症（OAB）中的作用。
共纳入 90 名女性患者：45 名在 Hopa 州立医院泌尿科综合诊所被诊断为 OAB 的女性患者和 45 名无任何代谢或神经疾病的健康女性。对所有受试者的 24 小时尿液样本进行 MDA 和 8-OHdG 水平的检测。
OAB 组的尿 MDA 和 8-OHdG 水平明显高于对照组（p<0.001）。8-OHdG 和 MDA 的检测结果之间存在显著的正相关（p<0.001）。
氧化应激可能在 OAB 的病理生理学中起重要作用，因为 8-OHdG 和 MDA 的水平升高。8-OHdG 水平升高可能是由于自由基引起的氧化攻击导致核和线粒体 DNA 受损所致。然而，仍需要进行更大样本量的随机和前瞻性研究。
